{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T19:45:56Z","timestamp":1791834356186,"version":"4.3.4"},"reference-count":20,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Hosp Palliat Care"],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Malignant biliary obstruction (MBO) is a common complication of advanced hepatopancreaticobiliary cancers, often presenting with jaundice, functional decline, and high symptom burden that significantly impairs quality of life. Percutaneous transhepatic biliary drainage (PTBD) is frequently used to relieve MBO when endoscopic drainage is not feasible, including patients receiving palliative care. However, evidence on clinical outcomes in palliative care populations remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate short-term clinical outcomes of PTBD in patients with advanced MBO receiving palliative care, focusing on 90-day mortality, clinical success, symptom control, functional status, procedure-related complications, reintervention, and access to chemotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This single-cohort, descriptive observational study included patients with MBO who underwent PTBD between 2022 and 2024. Patients were followed for 90 days after the procedure. Functional status was assessed using the Karnofsky Performance Status (KPS), and symptom burden was evaluated using the Edmonton Symptom Assessment System (ESAS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seventy-four patients were included (mean age: 65.5\u00a0years; 55.4% male). The most frequent malignancies were pancreatic cancer and cholangiocarcinoma. 90\u00a0days mortality after the procedure was 74.3%. Clinical success was achieved in 55.4% of cases. Symptomatic relief was observed for pruritus (95%) and pain (89%), although functional decline was noted. Procedure-related complications occurred in 23.0% of patients, and 43.2% required reintervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PTBD provided symptomatic relief; however, functional status declined and short-term mortality was high, consistent with the advanced disease stage of this cohort. These findings underscore the importance of individualized, comfort-focused decision-making aimed at optimizing symptom control and quality of life in palliative care patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10499091261495075","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T11:33:13Z","timestamp":1791545593000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Outcomes of Percutaneous Transhepatic Biliary Drainage in Patients With Malignant Biliary Obstruction Receiving Palliative Care"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7821-1833","authenticated-orcid":false,"given":"Mar\u00eda Ang\u00e9lica","family":"Rodr\u00edguez-Calderon","sequence":"first","affiliation":[{"name":"Fundaci\u00f3n Universitaria Sanitas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6785-8138","authenticated-orcid":false,"given":"Johana","family":"Benavides-Cruz","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Universitaria Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2017-3916","authenticated-orcid":false,"given":"Lina Andrea","family":"Mej\u00eda-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Universitaria Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9627-1678","authenticated-orcid":false,"given":"Diana Catalina","family":"Borda-Restrepo","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Universitaria Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.4251\/wjgo.v8.i6.498"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.4103\/jcrt.JCRT_521_19"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21208"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.11964"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-011-2121-7"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-007-0796-6"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1075.191746"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14194673"},{"key":"e_1_3_6_10_2","first-page":"1554","article-title":"Factors affecting survival in patients undergoing percutaneous transhepatic biliary drainage for malignant biliary obstruction","volume":"28","author":"Duzkopru Y","year":"2024","unstructured":"Duzkopru Y, Eren T, Kocanoglu A, Dogan O, Isak OA, Ergun O. Factors affecting survival in patients undergoing percutaneous transhepatic biliary drainage for malignant biliary obstruction. Eur Rev Med Pharmacol Sci. 2024;28:1554-1561.","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2014.1860"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/1457496917731192"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e24088"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2024.106772"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12029-022-00834-y"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-033576"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.5114\/ceh.2022.114190"},{"key":"e_1_3_6_18_2","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.15903"},{"key":"e_1_3_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2016.12.1208"},{"key":"e_1_3_6_20_2","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1075.173958"},{"key":"e_1_3_6_21_2","first-page":"282","article-title":"Mortality-related factors in patients with malignant obstructive jaundice","volume":"48","author":"Kurniawan J","year":"2016","unstructured":"Kurniawan J, Hasan I, Gani RA, Simadibrata M. Mortality-related factors in patients with malignant obstructive jaundice. 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