{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T22:29:55Z","timestamp":1783722595507,"version":"3.55.0"},"reference-count":14,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Thyroid\u00ae"],"published-print":{"date-parts":[[2025,10]]},"abstract":"\n Background:<\/jats:title>\n Thyroglobulin (Tg), stimulated or unstimulated by recombinant human thyrotropin (TSH), is a static marker of recurrent or persistent disease, and the Tg-doubling rate (Tg-DR) is a dynamic prognostic factor. This study evaluated the prognostic value of an unstimulated Tg (uTg) and Tg-DR papillary thyroid carcinoma (PTC).<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n This retrospective study included 1818 Tg antibody (Tg-Ab)-negative patients who underwent curative intent total thyroidectomy for PTC without distant metastasis. The uTg was measured 1\u20133 months post-surgery under TSH suppression (<0.1 mIU\/mL). We calculated the Tg-DR for patients, of whom postoperative Tg levels could be measured three or more times under TSH suppression.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Eighty-eight (4.8%) and 32 (1.8%) patients had respective local and distant recurrences (median follow-up period, 7.2 years; 25th percentile 4.7 years, 75th percentile 9.8 years). Of 1818 patients, 131 had a uTg \u22653 ng\/mL and were more likely to display local and distant recurrences in univariate and multivariable analyses (\n p<\/jats:italic>\n < 0.001). We divided 1212 patients with no adjuvant radioactive iodine treatment, of whom uTg and Tg-DR data were available, into four categories A, uTg \u22653 ng\/mL and Tg-DR \u22650.33\/year; B, uTg <3 ng\/mL and Tg-DR \u22650.33\/year; C, uTg \u22653 ng\/mL and Tg-DR <0.33\/year; and D, uTg <3 ng\/mL and Tg-DR <0.33\/year. The lymph node recurrence-free survival rate was significantly worse from category A to D (A vs. B,\n p<\/jats:italic>\n < 0.001, hazard ratio or HR [CI]: 5.083 [1.994\u201312.955]; B vs. C,\n p<\/jats:italic>\n = 0.001, HR [CI]: 2.654 [1.462\u20134.824]; C vs. D,\n p<\/jats:italic>\n < 0.001, HR [CI]: 27.420 [15.100\u20134.980]). The distant recurrence-free survival rate (DR-FS) of category B did not differ from that of category C (\n p<\/jats:italic>\n = 0.419), but DR-FS of category D was better (\n p<\/jats:italic>\n < 0.001) than those of B and C, and that of category A tended to be worse (\n p<\/jats:italic>\n = 0.087) compared with those of B and C. Patients in category A, categories B and C, and category D could thus be classified as high-risk, intermediate-risk, and low-risk for distant recurrence, respectively.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n This study demonstrates the prognostic value of postoperative uTg and Tg-DR in Tg-Ab-negative patients with PTC under TSH suppression after total thyroidectomy. Prospective studies are needed to confirm these findings.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/10507256251367242","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T18:52:36Z","timestamp":1759949556000},"page":"1153-1161","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Dynamic Risk Assessment Using Unstimulated Serum Thyroglobulin Level and Thyroglobulin Doubling Rate after Total Thyroidectomy for Papillary Thyroid Carcinoma"],"prefix":"10.1177","volume":"35","author":[{"given":"Yasuhiro","family":"Ito","sequence":"first","affiliation":[{"name":"Department of Surgery, Kuma Hospital, Kobe, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0041-197X","authenticated-orcid":false,"given":"Akira","family":"Miyauchi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Kuma Hospital, Kobe, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9447-6602","authenticated-orcid":false,"given":"Masashi","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Surgery, Kuma Hospital, Kobe, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoru","family":"Kihara","sequence":"additional","affiliation":[{"name":"Department of Surgery, Kuma Hospital, Kobe, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoyoshi","family":"Onoda","sequence":"additional","affiliation":[{"name":"Department of Surgery, Kuma Hospital, Kobe, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Miya","sequence":"additional","affiliation":[{"name":"Department of Surgery, Kuma Hospital, Kobe, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,8,11]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1530\/ETJ-24-0196"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0039-6060(03)00384-2"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/1067447"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0020"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1530\/ETJ-21-0046"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2010.0355"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2018.07.045"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ24-0644"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12893-022-01819-1"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2016.0031"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/MNM.0000000000001154"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000347148"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/wjs.12325"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-11-1029"}],"container-title":["Thyroid\u00ae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10507256251367242","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10507256251367242","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10507256251367242","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T08:56:17Z","timestamp":1780044977000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10507256251367242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,11]]},"references-count":14,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1177\/10507256251367242"],"URL":"https:\/\/doi.org\/10.1177\/10507256251367242","relation":{},"ISSN":["1050-7256","1557-9077"],"issn-type":[{"value":"1050-7256","type":"print"},{"value":"1557-9077","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,11]]}}}