{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T11:09:38Z","timestamp":1789729778692,"version":"4.0.1"},"reference-count":60,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T00:00:00Z","timestamp":1756857600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Thyroid\u00ae"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Anaplastic thyroid carcinoma (ATC) represents a rare yet highly malignant histotype of thyroid cancer. Cancer-associated fibroblasts (CAFs) play a pivotal role in tumor cell invasion, migration, and angiogenesis and present a potential target for cancer treatment. We aimed to investigate the effects of modulating specific subsets of CAFs on the proliferation, invasion, and migration of ATC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      We developed nanosystems, platelet-derived growth factor receptor (PDGFR-\u03b2) targeted-polypeptide-modified poly (\u03b2-amino ester) (pBAE) (T-pBAE)\/si\n                      <jats:italic toggle=\"yes\">B7-H3<\/jats:italic>\n                      nanoparticles (NPs), targeting PDGFR-\u03b2+ CAFs and featuring B7-H3 knockdown. We evaluated both the targeting efficacy and gene silencing performance of T-pBAE\/si\n                      <jats:italic toggle=\"yes\">B7-H3<\/jats:italic>\n                      NPs, as well as the functional contribution of B7-H3 to CAFs-driven ATC progression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      T-pBAE\/si\n                      <jats:italic toggle=\"yes\">B7-H3<\/jats:italic>\n                      NPs were efficiently internalized by CAFs, achieving targeted knockdown of B7-H3 expression. Silencing B7-H3 significantly suppressed the expression of cell division cycle 27 and other cell cycle-related genes, thereby inhibiting CAFs\u2019 proliferation. Consequently, CAFs-secreted cytokines (e.g., CCL1 and CCL4) were altered. Through modulation of cytokine receptor activation on ATC cells, this process reduced ATC cell proliferation, invasion, and migration. In mice ATC subcutaneous tumor models, local injection of T-pBAE\/si\n                      <jats:italic toggle=\"yes\">B7-H3<\/jats:italic>\n                      NPs reduced tumor volume. Moreover, the expression of invasive proliferation-related markers (PDGFR-\u03b2, Ki-67, CD31), immune evasion-related marker CD163, and chemoresistance-related marker ATP-binding cassette subfamily G member 2 was remarkably downregulated in tumor tissues.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study demonstrates that PDGFR-\u03b2 polypeptide-modified pBAE could successfully deliver B7-H3 siRNA to CAFs. After knockdown of B7-H3 within CAFs, ATC proliferation, invasion, and migration were inhibited. Overall, our findings revealed that B7-H3 can be a promising therapeutic target for ATC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10507256251372644","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T18:52:36Z","timestamp":1759949556000},"page":"1173-1186","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Targeting B7-H3 in Cancer-Associated Fibroblasts Using Nanosystems Suppresses Anaplastic Thyroid Carcinoma Progression"],"prefix":"10.1177","volume":"35","author":[{"given":"Tong","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Ultrasound Medicine, The First Affiliated Hospital of Soochow University, Suzhou, China."},{"name":"Department of Ultrasound, The Second Affiliated Hospital of Soochow University, Suzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xudong","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University, Suzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongken","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, The Second Affiliated Hospital of Soochow University, Suzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lichen","family":"Yin","sequence":"additional","affiliation":[{"name":"Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University, Suzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Soochow University, Suzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjian","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixue","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Breast and Thyroid Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peifeng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, The Second Affiliated Hospital of Soochow University, Suzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Hu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Radiation Medicine and 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