{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T14:20:49Z","timestamp":1791555649039,"version":"4.3.4"},"reference-count":46,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T00:00:00Z","timestamp":1766620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Thyroid\u00ae"],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>There is evidence of quality of life (QoL) impairment and weight gain in treated hyperthyroidism. It is not known whether treatment-related weight gain is associated with QoL impairment in this patient group of this cohort. Our primary aim was to examine whether percentage weight gain (PWG) after treatment of hyperthyroidism was associated with QoL impairment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We enrolled patients with treated hyperthyroidism 6 months to 8 years after diagnosis. We obtained anthropometric measurements from a prospectively completed database. With a cross-sectional study design, we assessed QoL using the thyroid-specific patient-reported outcome (ThyPRO) tool. We pre-specified three dependent variables in ThyPRO: \u201ccosmetic complaints,\u201d a composite of \u201ctiredness and overall QoL\u201d and \u201cdepressivity and anxiety\u201d domains. We included age, sex, thyrotropin categories, comorbidities, and disease duration as covariates. We applied a generalized linear model (GLM) for the analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      We included 108 patients, including 68 (63%) females, with a mean (standard deviation [SD]) age 50 (14.5) years. The median weight at diagnosis was 65.5 (interquartile range [IQR]: 58.7, 75.5) kg and BMI was 23.9 (21.9, 27.1) kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      , and at final evaluation, weight was 72.7 (64.1, 83.8) kg (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001) and BMI was 26.5 (23.9, 30.8) kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001). The mean (SD) weight gain observed was 7.2 (6.2) kg over a mean (SD) disease duration of 41 (22.5) months. Median PWG was 8.8% (4.3%, 17%). There was a significantly reduced QoL in all comparable domains against general population normative data. PWG was associated with \u201ccosmetic complaints\u201d (odds ratio = 1.11,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.008 via logistic regression; b = 0.47,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.022, q (adjusted p) = 0.033 via GLM) and \u201ctiredness and overall QoL\u201d (b = 0.62,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.011, q = 0.017), but\u00a0not with the \u201canxiety and depressivity\u201d domains (b = \u22120.005,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.661).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Our study suggests that weight gain after treatment of hyperthyroidism is associated with a large adverse effect on QoL, with reduced scores on appearance, combined \u201ctiredness and overall QoL\u201d domains of the ThyPRO questionnaire. Management of weight change upon treatment of hyperthyroidism merits further clinical attention and research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10507256251404868","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T02:41:54Z","timestamp":1766716914000},"page":"25-35","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Weight Gain after Treatment of Hyperthyroidism is Associated with Impairment of Quality of Life"],"prefix":"10.1177","volume":"36","author":[{"given":"Angelos","family":"Kyriacou","sequence":"first","affiliation":[{"name":"School of Medicine, European University Cyprus, Nicosia, Cyprus."},{"name":"Diabetes and Metabolism, CEDM Centre of Endocrinology, Limassol, Cyprus."},{"name":"Diabetes, Endocrinology, and Obesity Medicine, Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust, Salford, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Kyriacou","sequence":"additional","affiliation":[{"name":"Diabetes and Metabolism, CEDM Centre of Endocrinology, Limassol, Cyprus."},{"name":"School of Health Sciences, University of Stirling, Stirling, UK."},{"name":"Center of Excellence in Biobanking and Biomedical Research, University of Cyprus, Nicosia, Cyprus."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demetris","family":"Lamnisos","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, European University Cyprus, Nicosia, Cyprus."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliki","family":"Economides","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, European University Cyprus, Nicosia, Cyprus."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panayiotis","family":"Economides","sequence":"additional","affiliation":[{"name":"School of Medicine, European University Cyprus, Nicosia, Cyprus."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petros","family":"Perros","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute, University of Newcastle, Newcastle upon Tyne, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akheel A.","family":"Syed","sequence":"additional","affiliation":[{"name":"Diabetes, Endocrinology, and Obesity Medicine, Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust, Salford, UK."},{"name":"Division of Diabetes, Endocrinology, and Gastroenterology, Faculty of Biology, Medicine, and Health, The University of Manchester, Manchester, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,12,25]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/9863050"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/METABO12040336"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200010263431707"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/CEN.14873"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2001.01329.x"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2018.0731"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1530\/ETJ-24-0373"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/cob.12328"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1089\/ct.2025;37.234-237"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1210\/CLINEM\/DGAA754"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1089\/THY.2016.0044"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1089\/THY.2019.0085"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2018.0315"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1089\/THY.2011.0153"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1089\/THY.2005.15.1279"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1530\/EJE.1.02124"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/J.1525-1497.2000.90906.X"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-09-0521"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1210\/JC.2014-1322"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1089\/THY.2014.0433"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/oso\/9780195171693.001.0001"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/S42000-018-0015-7"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.8.910"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40211-019-0302-9"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1467-789x.2001.00040.x"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.JSS.2014.07.061"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.11606\/S1518-8787.2017051006882"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/GERONA\/62.3.281"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0239835"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2020.0881"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.ARR.2019.04.005"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1530\/ETJ-23-0040"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/S12020-018-1733-Y"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.1089\/whr.2023.0073"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.3390\/IJERPH18115951"},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.1186\/S12889-020-8212-0\/TABLES\/5"},{"key":"e_1_3_5_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.ARCHGER.2019.05.009"},{"key":"e_1_3_5_39_2","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.69.808.107"},{"key":"e_1_3_5_40_2","doi-asserted-by":"publisher","DOI":"10.1136\/BMJOPEN-2021-055219"},{"key":"e_1_3_5_41_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2016.0229"},{"issue":"2","key":"e_1_3_5_42_2","first-page":"242","article-title":"Weight 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Weight homeostasis &amp; its modulators in hyperthyroidism before & after treatment with carbimazole. 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