{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T15:32:37Z","timestamp":1793287957258,"version":"4.5.0"},"reference-count":20,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Thyroid\u00ae"],"published-print":{"date-parts":[[2026,2,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Pretibial dermopathy (PTD) is a rare, disfiguring manifestation of Graves\u2019 disease. The shared pathophysiology with thyroid eye disease (TED), centered on fibroblast activation via a thyroid-stimulating hormone receptor and insulin-like growth factor-1 receptor (IGF-1R) complex, provides a strong rationale for using the IGF-1R inhibitor, teprotumumab.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We present a case series of five patients with severe PTD and concomitant TED who were treated with teprotumumab. A review of reported cases in the literature was also conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>All patients experienced significant clinical improvement, including regression of skin thickening as well as enhanced functional capacity. Side effects included mild hearing loss, muscle cramps, and fatigue. One patient experienced a severe gastrointestinal event requiring treatment discontinuation, while those experiencing a recurrence of PTD, responded to a second course of therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Teprotumumab showed promising efficacy in the treatment of PTD. Further studies are needed to confirm its durability and safety.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10507256251414948","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T07:44:21Z","timestamp":1768376661000},"page":"213-218","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Beyond the Eyes: Is Teprotumumab Effective for Thyroid Dermopathy?"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4776-1918","authenticated-orcid":false,"given":"Dana","family":"Hamadi","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Hennepin Healthcare, Minneapolis, MN, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhail","family":"Saad-Omer","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, Rochester, MN, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Toro-Tobon","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, Rochester, MN, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius N.","family":"Stan","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, Rochester, MN, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,1,13]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8529(18)30486-9"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.2.8220"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200506050-00003"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2018.0706"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s42000-021-00282-6"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/jca.20244"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.14740\/jocmr2303w"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2023.0167"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-021-01593-z"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-022-01804-1"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2020.09.003"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2021.08.026"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1530\/EDM-21-0201"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.6621"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.36849\/JDD.6854"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcemcr\/luac037"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.5070\/D329160211"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajoc.2024.102031"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2024-260129"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1210\/jendso\/bvae163.2099"}],"container-title":["Thyroid\u00ae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10507256251414948","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10507256251414948","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10507256251414948","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T14:45:23Z","timestamp":1793285123000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10507256251414948"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,13]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2,1]]}},"alternative-id":["10.1177\/10507256251414948"],"URL":"https:\/\/doi.org\/10.1177\/10507256251414948","relation":{},"ISSN":["1050-7256","1557-9077"],"issn-type":[{"value":"1050-7256","type":"print"},{"value":"1557-9077","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,13]]}}}