{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:36:56Z","timestamp":1793320616432,"version":"4.5.0"},"reference-count":53,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100004897","name":"European Organisation for Research and Treatment of Cancer","doi-asserted-by":"crossref","award":["Quality of Life Group #002\/2017"],"award-info":[{"award-number":["Quality of Life Group #002\/2017"]}],"id":[{"id":"10.13039\/501100004897","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Thyroid\u00ae"],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The health-related quality of life (HRQoL) of patients with differentiated thyroid carcinoma (DTC), especially their mental health, can be compromised by various factors beyond disease prognosis and treatment stage. However, predictors of poor emotional functioning (EF) in DTC patients have not been thoroughly studied. To inform targeted interventions that could improve or preserve HRQoL in patients with DTC, this study aimed to identify predictors of impaired EF, and particularly modifiable factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Data analyzed were from the phase IV international validation study of the European Organization for Research and Treatment of Cancer thyroid cancer-specific HRQoL questionnaire (QLQ-THY34). Patients (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 196) were assessed at three timepoints before treatment (t1), 6 weeks after the start of treatment (t2), and 6 months after t2 (t3). Multilevel, multivariable logistic regression models were used to assess the likelihood of impaired EF at t3 according to predefined potential predictors at t1 and t2.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Impaired EF at t1 or t2 predicted impaired EF at t3. Exhaustion, head and neck discomfort and body image issues were significantly associated with poor EF at t3. More specifically, temporal changes of these three variables from t1 to t2 were independent predictors of poor EF at t3 with an odds ratio of 1.04 (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001), 1.01 (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.04), and 1.01 (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.001) per score point, respectively. There was no evidence that worry about important others, lacking social support, sex, stage, or Karnofsky performance score are associated with EF at t3.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Exhaustion, head and neck discomfort, and body image concerns emerged as modifiable factors that predict future impaired EF in patients with DTC undergoing treatment. These factors could be targeted in prehabilitation, rehabilitation or other interventional programs to potentially improve or preserve patients\u2019 EF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10507256261442504","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T09:19:03Z","timestamp":1776071943000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Prospective Predictors of Poor Emotional Functioning in Patients with Differentiated Thyroid Carcinoma"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9565-4941","authenticated-orcid":false,"given":"Gerasimos P.","family":"Sykiotis","sequence":"first","affiliation":[{"name":"Service of Endocrinology, Diabetes, and Metabolism, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athina","family":"Mageiropoulou","sequence":"additional","affiliation":[{"name":"Service of Endocrinology, Diabetes, and Metabolism, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akram","family":"Al-Ibraheem","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, King Hussein Cancer Center, Amman, Jordan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Pinto","sequence":"additional","affiliation":[{"name":"Rehabilitation Medicine Department, Istituto Nazionale Tumori \u2013 IRCCS \u2013 Fondazione G. Pascale, Naples, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Iakovou","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Aristotle University, Thessaloniki, Greece."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arild Andre","family":"\u00d8sthus","sequence":"additional","affiliation":[{"name":"ENT and Head and Neck Department, Oslo University Hospital, Norway."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Gamper","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Department of Psychiatry, Psychotherapy and Psychosomatic Medicine, University Hospital Psychiatry II, Medical University of Innsbruck, Innsbruck, Austria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Hammerlid","sequence":"additional","affiliation":[{"name":"Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden."},{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, Sahlgrenska University Hospital, Gothenburg, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Deborah","family":"Locati","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy."},{"name":"Medical Oncology Unit, Istituti Clinici Scientifici Maugeri IRCCS, Pavia, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Ribeiro","family":"Gama","sequence":"additional","affiliation":[{"name":"Head and Neck Surgery Department, Barretos Cancer Hospital, Barretos, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Fanetti","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Kiyota","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Hematology, Cancer Center, Kobe University Hospital, Kobe, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Ignacio","family":"Arraras","sequence":"additional","affiliation":[{"name":"Oncology Department, Complejo Hospitalario de Navarra, Pamplona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Inhestern","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Jena, Jena, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Ioannidis","sequence":"additional","affiliation":[{"name":"Oncology Department, Nicosia General Hospital, State Health Services Organization, Nicosia, Cyprus."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Canotilho","sequence":"additional","affiliation":[{"name":"Instituto Portugu\u00eas do Oncologia do Porto Francisco Gentil, Porto, Portugal."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Husson","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, Netherlands."},{"name":"Departments of Surgical Oncology and Public Health, Erasmus University Medical Center, Rotterdam, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Andry","sequence":"additional","affiliation":[{"name":"Surgery Department, Jules Bordet Institute, Brussels, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Rimmele","sequence":"additional","affiliation":[{"name":"Bundesverband Schilddr\u00fcsenkrebs - Ohne Schilddr\u00fcse leben e. 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