{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T12:07:33Z","timestamp":1789214853921,"version":"build-2803163510"},"reference-count":36,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"crossref","award":["2023A1515011300"],"award-info":[{"award-number":["2023A1515011300"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003785","name":"Guangdong Medical Research Foundation","doi-asserted-by":"crossref","award":["B2025186"],"award-info":[{"award-number":["B2025186"]}],"id":[{"id":"10.13039\/501100003785","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Thyroid\u00ae"],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      In the current conventional recombinant human thyrotropin (rhTSH) protocol, radioiodine therapy (RAIT) is given at 24 h post-second injection and diagnostic\n                      <jats:sup>131<\/jats:sup>\n                      I whole-body scan (Dx-WBS) at 72 h; hence, Dx-WBS cannot precede RAIT within the same two-injection cycle. This study aimed to evaluate whether Dx-WBS could be performed within 24 hours after the second injection of a novel rhTSH, thereby enabling timely pre-RAIT evaluation without altering the established rhTSH-based RAIT schedule.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      This single-center, prospective trial enrolled patients with differentiated thyroid carcinoma (DTC) who had undergone total thyroidectomy. All patients received rhTSH (0.9 mg daily) on 2 consecutive days. On the same day, about 6 hours after the second rhTSH injection, a low-dose diagnostic activity of\n                      <jats:sup>131<\/jats:sup>\n                      I was given, followed by Dx-WBS at approximately 12, 18, and 24 hours post-administration. RAIT was administered on the same day following the 24-hour Dx-WBS, and post-treatment whole-body scan (Rx-WBS) served as the reference standard for assessing concordance with Dx-WBS. Thyroglobulin (Tg) and anti-thyroglobulin antibody (TgAb) levels were measured at baseline and at 6, 24, and 72 hours following the second rhTSH injection. In TgAb-negative patients, sTg values were stratified into three categories (&lt;1, 1\u201310, and \u226510 ng\/mL), and concordance of 6h- and 24h-sTg with 72h-sTg was assessed based on identical categorization.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 110 patients were eventually enrolled, concordance rates of 12h-, 18h-, and 24h-Dx-WBS with Rx-WBS were 82.7% [CI: 74.3\u201389.3%], 91.8% [CI: 85.0\u201396.2%], and 92.7% [CI: 86.2\u201396.8%], respectively. Concordance at both 18 and 24 hours was significantly higher than that at 12 hours (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.05). The concordance rate of 24-hour sTg with 72-hour sTg was significantly higher than that of 6-hour sTg (89.3%, [CI: 80.1\u201395.3%] vs. 72.0%, [CI: 60.4\u201381.8%],\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The rhTSH-aided Dx-WBS and sTg, performed within 24 hours post-second rhTSH injection, are reliable and efficient in enabling pre-RAIT disease evaluation and subsequent RAIT within the same two-injection cycle, providing a cost-effective strategy.<\/jats:p>\n                  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