{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T02:18:55Z","timestamp":1783649935514,"version":"3.55.0"},"reference-count":31,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Back and Musculoskeletal Rehabilitation"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ozone (O2-O3) therapy, is a novel and increasingly utilized intervention in musculoskeletal medicine. This therapeutic approach has gained attention for its potential in managing conditions such as chronic pain, arthritis, and soft tissue injuries, offering a minimally invasive alternative to conventional treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to explore the effectiveness of multiple-dose ozone injections in subacromial impingement syndrome (SAIS) and to compare it with single-dose ozone and corticosteroids regarding patient-related clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This single-center prospective randomized controlled clinical trial comprised 108 SAIS patients divided into three groups: Group 1, multiple-dose ozone (50 mcg ozone\/ week for five weeks); Group 2, single-dose ozone (50 mcg ozone) and Group 3, single-dose corticosteroid (40\u2005mg triamcinolone). The pain, functionality, and quality of life of the patients were evaluated via the Visual Analogue Scale (VAS), Constant-Murley score (CMS), University of California Los Angeles Shoulder Scale (UCLA), and 36-Item Survey Short-Form (SF-36) in three, six and twelve months. ANOVA\/Friedman's test was applied to evaluate the statistical differences between the groups for each outcome measure at each time point.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mean age of the study population was 53.3\u2009\u00b1\u20093.1 years, and 52.8% of them were female. In the first week, the steroid group scored less than the other two groups (p\u2009&lt;\u20090.001) in VAS. At 3, 6, and 12 months, CMS was significantly higher in the multiple ozone group compared to the other two groups (p\u2009&lt;\u20090.001 for all). UCLA scores increased in all groups, with the greatest improvement observed in the multiple ozone group. After 12 months, all groups differed significantly in SF-36 scores (65.0 [11.0] in the multiple-ozone group, 43.5 [4.8] in the ozone group, and 40.0 [11.0] in the steroid group, p\u2009&lt;\u20090.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Multiple ozone (O2-O3) injections had better patient-related outcomes regarding pain, functioning, and quality of life in patients with SAIS in 3-m, 6-m, and one-year follow-up periods.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10538127251322859","type":"journal-article","created":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T19:23:17Z","timestamp":1742930597000},"page":"1031-1043","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparing the clinical efficacy of multiple vs. single dose ozone (O2-O3) injections and corticosteroid injection in subacromial impingement syndrome: A prospective, randomized controlled trial with One-Year Follow-Up"],"prefix":"10.1177","volume":"38","author":[{"given":"Mehmet Cenk","family":"Turgut","sequence":"first","affiliation":[{"name":"Department of Orthopedics and Traumatology, Erzurum Regional Training and Research Hospital, Erzurum, T\u00fcrkiye"},{"name":"Department of Orthopedics and Traumatology, Ataturk University Training and Research Hospital, Erzurum, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yavuz","family":"\u015eahbat","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Erzurum Regional Training and Research Hospital, Erzurum, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Af\u015far","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Ataturk University Training and Research Hospital, Erzurum, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asl\u0131","family":"Turgut","sequence":"additional","affiliation":[{"name":"Department of Radiology, Erzurum Regional Training and Research Hospital, Erzurum, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammed \u00c7a\u011fatay","family":"Engin","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Ataturk University Training and Research Hospital, Erzurum, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonca Sa\u011flam","family":"Akkaya","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Erzurum Regional Training and Research Hospital, Erzurum, T\u00fcrkiye"},{"name":"Faculty of Medicine, Department of Physical Medicine and Rehabilitation, Karadeniz Technical University, Trabzon, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,3,25]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/19417381221108726"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmr.2022.12.001"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b5319"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/pmrj.12042"},{"key":"e_1_3_3_6_2","first-page":"64","article-title":"Safety of intra-articular glucocorticoid injections - state of the art","volume":"2","author":"Duarte-Monteiro AM","year":"2023","unstructured":"Duarte-Monteiro AM, Dourado E, Fonseca JE, et al. Safety of intra-articular glucocorticoid injections - state of the art. ARP Rheumatol 2023; 2: 64\u201373.","journal-title":"ARP Rheumatol"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/1759720X211037530"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3344\/kjp.22221"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.knee.2021.08.008"},{"key":"e_1_3_3_10_2","first-page":"61","article-title":"Interesting effectiveness of ozone injection for carpal tunnel syndrome treatment: a randomized controlled trial","volume":"11","author":"Bahrami MH","year":"2019","unstructured":"Bahrami MH, Raeissadat SA, Nezamabadi M, et al. Interesting effectiveness of ozone injection for carpal tunnel syndrome treatment: a randomized controlled trial. Orthop Res Rev 2019; 11: 61\u201367.","journal-title":"Orthop Res Rev"},{"key":"e_1_3_3_11_2","article-title":"Ultrasound-guided shoulder intraarticular ozone injection versus pulsed radiofrequency application for shoulder adhesive capsulitis: a randomized controlled trial","volume":"26","author":"Foula AS","year":"2023","unstructured":"Foula AS, Sabry LS, Elmulla AF, et al. Ultrasound-guided shoulder intraarticular ozone injection versus pulsed radiofrequency application for shoulder adhesive capsulitis: a randomized controlled trial. 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A double blind clinical trial","volume":"1","author":"Ikonomidis S","year":"2002","unstructured":"Ikonomidis S, Iliakis E, Charalambus Dvakirtzian L. Nonoperative treatment of shoulder impingement syndrome with topical injections of medical oxygen-ozone mixture. A double blind clinical trial. Rivista Italiana di Ossigeno-Ozonoterapia 2002; 1: 41\u201344.","journal-title":"Rivista Italiana di Ossigeno-Ozonoterapia"},{"key":"e_1_3_3_26_2","first-page":"20","article-title":"O2-O3 THERAPY IN TENDINOPATHIES AND ENTRAPMENT SYNDROME","volume":"4","author":"Moretti B","year":"2005","unstructured":"Moretti B, Lazisera R, Sisti G, et al. O2-O3 THERAPY IN TENDINOPATHIES AND ENTRAPMENT SYNDROME. 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