{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:41:53Z","timestamp":1792104113221,"version":"4.4.0"},"reference-count":53,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Back and Musculoskeletal Rehabilitation"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Tendons are among the most frequently affected structures in musculoskeletal disorders. Polynucleotides (PNs) have been proposed to promote tendon regeneration by enhancing collagen synthesis and reducing inflammation. This retrospective clinical study aimed to evaluate the clinical effects of PNs injections in patients with different kinds of tendinopathy (mostly gluteal tendinopathy, biceps brachii tendinopathy and Achilles tendinopathy), focusing on pain reduction and functional improvement.\n                    <jats:bold>Methods:<\/jats:bold>\n                    Sixty-eight patients with clinically diagnosed tendinopathy received three peritendinous injections of a PNs-based medical device at baseline (T0), two weeks (follow-up 1), and four weeks (follow-up 2) post-T0. Follow-up assessments were conducted at follow-up 1, follow-up 2-, eight- and 24-weeks post-follow-up 2. The primary outcome was pain reduction measured by the numerical rating scale (NRS). Secondary outcomes included pain-related functional limitation (VAS-function), the Clinical Global Impression\u2013Improvement scale, and patient satisfaction on a 5-point Likert scale.\n                    <jats:bold>Results:<\/jats:bold>\n                    A mean NRS and VAS-function reduction of, respectively, \u22121.76\u2009\u00b1\u20090.08 and \u22121.74\u2009\u00b1\u20090.07 were found per follow-up, with statistically significant improvements over time. At the final follow-up, 88% of patients reported being \u201csatisfied\u201d or \u201cvery satisfied\u201d with the treatment.\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    The results support the efficacy and safety of PNs treatment in patients with tendinopathies, as it led to significant improvements in pain and function. Further high-quality clinical studies are needed to validate these findings.\n                  <\/jats:p>","DOI":"10.1177\/10538127251391098","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T17:15:39Z","timestamp":1761758139000},"page":"649-660","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical benefits and safety of polynucleotides injections for the treatment of tendinopathies: A multicenter, single-cohort, retrospective study"],"prefix":"10.1177","volume":"39","author":[{"given":"Domiziano","family":"Tarantino","sequence":"first","affiliation":[{"name":"Department of Public Health, University of Naples Federico II, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Ruosi","sequence":"additional","affiliation":[{"name":"IRCCS Humanitas Research Hospital, Department of Biomedical Sciences, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Di Iorio","sequence":"additional","affiliation":[{"name":"Department of Innovative Technologies in Medicine &amp; Dentistry, University \u201cG. d\u2019Annunzio\u201d, Chieti-Pescara, Italy"},{"name":"\u201cDe Cesaris\u201d Nursing Home, Synergo-Group, Piazza Pierangeli, Pescara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raoul","family":"Saggini","sequence":"additional","affiliation":[{"name":"Faculty of Psychology, eCampus University, Novedrate, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Barassi","sequence":"additional","affiliation":[{"name":"Center for Physiotherapy, Rehabilitation and Re-Education (Ce.Fi.R.R.), Venue \u201cG. d'Annunzio\u201d University of Chieti-Pescara, Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaello","family":"Pellegrino","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, LUM University, Casamassima, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"For the Italian Tendinopathies study group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,10,29]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.csm.2015.06.010"},{"key":"e_1_3_3_3_2","doi-asserted-by":"crossref","unstructured":"Aicale R Tarantino D Maffulli N. 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