{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:37:30Z","timestamp":1792841850600,"version":"4.5.0"},"reference-count":49,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Back and Musculoskeletal Rehabilitation"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Neuropathic pain secondary to lumbar spinal pathology is often refractory to conventional treatments, prompting interest in ozone therapy because of its anti-inflammatory and neuromodulatory effects. However, treatment outcomes vary, and factors influencing remission duration remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the influence of demographic variables and ozone therapy parameters on symptom remission duration in patients with lower-limb peripheral neuropathic pain treated with subcutaneous oxygen\u2013ozone injections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study included 304 patients with lower-extremity neuropathic pain who achieved initial symptom remission after subcutaneous O\u2082\/O\u2083 injections. The primary outcome was time to pain recurrence up to 18 years. Variables analyzed included age, sex, number of treatment sessions, and ozone concentration. All patients received a constant total ozone dose of 800 \u03bcg. Statistical analysis included two-way ANCOVA, Kruskal\u2013Wallis testing, and Spearman correlation analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Recovery duration differed significantly according to patient age and ozone concentration. An optimal ozone concentration of approximately 21\u2005\u03bcg O\u2083\/mL O\u2082 was identified. Increasing ozone concentration was associated with a reduction in recovery duration of approximately 1.8% per unit increase. Age demonstrated a significant negative correlation with recovery duration (p\u2009&lt;\u20090.01), with an estimated 0.2% decrease per additional year of age. No association was found between age and ozone concentration. Sex and number of treatment sessions were not significantly associated with outcome duration. Lower-to-middle ozone concentrations were associated with longer recovery duration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Subcutaneous oxygen\u2013ozone therapy provided sustained clinical benefit in patients with peripheral neuropathic pain secondary to lumbar spinal disorders. Demographic outcomes highlight the importance of individualized dose selection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10538127261444793","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T12:02:47Z","timestamp":1779278567000},"page":"1923-1933","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical analysis of demographic variables and factors contributing to outcomes in peripheral neuropathy secondary to lumbar spinal disorders following ozone therapy: A retrospective study"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8595-5677","authenticated-orcid":false,"given":"Ioannis","family":"Iliakis","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Asklipeion Voulas General Hospital, Voula, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanouil","family":"Iliakis","sequence":"additional","affiliation":[{"name":"Orthopaedic Surgeon, Ozonaim Clinic, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1585-6544","authenticated-orcid":false,"given":"Demitrios","family":"Vynios","sequence":"additional","affiliation":[{"name":"Biochemical Analysis &amp; Matrix Pathobiochemistry Research Group, Department of Chemistry, University of Patras, Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4991-0289","authenticated-orcid":false,"given":"Emma","family":"Borrelli","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnologies, University of Siena, Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.4184\/asj.2017.11.4.661"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/papr.12023"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2012.07.029"},{"key":"e_1_3_3_5_2","first-page":"41","article-title":"Treatment of the lumbar disc herniation with intradiscal and intraforaminal injection of oxygen-ozone","volume":"89","author":"Zhang Y","year":"2018","unstructured":"Zhang Y, Ma Y, Jiang J, et al. 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