{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:37:47Z","timestamp":1792841867488,"version":"4.5.0"},"reference-count":60,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T00:00:00Z","timestamp":1778284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Back and Musculoskeletal Rehabilitation"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Low back pain (LBP) is a major global disability, yet the promise of regenerative medicine using platelet-rich plasma (PRP) remains debated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To systematically evaluate the efficacy of PRP injections in reducing pain intensity and pain-related disability in patients with LBP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic search of PubMed, Embase, and the Cochrane Library identified randomized controlled trials evaluating the effects of PRP on low back pain. The primary outcomes were changes in pain intensity, measured by the Visual Analog Scale (VAS) or Numeric Rating Scale (NRS), and pain-related disability, assessed using the Oswestry Disability Index (ODI) or the Roland\u2013Morris Disability Questionnaire (RMDQ), at follow-ups of 1 week and 1, 2, 3, 4, and 6 months. A random-effects model was applied for the meta-analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This meta-analysis of 15 RCTs (740 patients) showed that PRP injections significantly reduced pain (SMD: \u22121.32; 95% CI: \u22122.06 to \u22120.59; P\u2009=\u20090.001) and reduced pain-related disability (SMD: \u22121.04; 95% CI: \u22121.66 to \u22120.41; P\u2009&lt;\u20090.001) compared to controls. Significant benefits were observed at 1, 2, 3, and 6 months. Subgroup analysis showed significant improvement in discogenic pain at 1 month, but later effects were inconsistent, whereas non-discogenic pain improved consistently across all time points.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PRP injections reduced LBP and reduced pain-related disability for up to 6 months. For discogenic pain, a significant benefit was detected at 1 month, whereas longer-term effects could not be reliably demonstrated due to high heterogeneity, while non-discogenic pain improved consistently at 6 months. However, these findings should be interpreted cautiously due to substantial heterogeneity across studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10538127261448983","type":"journal-article","created":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T15:03:36Z","timestamp":1778339016000},"page":"1830-1844","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Platelet-rich plasma therapy for low back pain: A comprehensive systematic review and meta-analysis"],"prefix":"10.1177","volume":"39","author":[{"given":"Xiaolong","family":"Pei","sequence":"first","affiliation":[{"name":"Division of Spine, Department of Orthopedics, Tongji Hospital, Tongji University School of Medicine, Tongji University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhua","family":"Liu","sequence":"additional","affiliation":[{"name":"Lishui Hospital of Traditional Chinese Medicine, Affiliated to Zhejiang University of Chinese Medicine, Lishui City, Zhejiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayan","family":"Wang","sequence":"additional","affiliation":[{"name":"Graduate Joint Training Base, Zhejiang Chinese Medical University, Hangzhou City, Zhejiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huajian","family":"Lin","sequence":"additional","affiliation":[{"name":"Lishui Hospital of Traditional Chinese Medicine, Affiliated to Zhejiang University of Chinese Medicine, Lishui City, Zhejiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zegen","family":"Ye","sequence":"additional","affiliation":[{"name":"Lishui Hospital of Traditional Chinese Medicine, Affiliated to Zhejiang University of Chinese Medicine, Lishui City, Zhejiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqin","family":"Wang","sequence":"additional","affiliation":[{"name":"Lishui Hospital of Traditional Chinese Medicine, Affiliated to Zhejiang University of Chinese Medicine, Lishui City, Zhejiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binbin","family":"Wu","sequence":"additional","affiliation":[{"name":"Lishui Hospital of Traditional Chinese Medicine, Affiliated to Zhejiang University of Chinese Medicine, Lishui City, Zhejiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Jin","sequence":"additional","affiliation":[{"name":"Lishui Hospital of Traditional Chinese Medicine, Affiliated to Zhejiang University of Chinese Medicine, Lishui City, Zhejiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,9]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19052964"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.8105.2"},{"key":"e_1_3_4_4_2","first-page":"223","article-title":"Acute lumbar back pain: investigation, differential diagnosis, and treatment","volume":"113","author":"Casser H-R","year":"2016","unstructured":"Casser H-R, Seddigh S, Rauschmann M. Acute lumbar back pain: investigation, differential diagnosis, and treatment. Dtsch Arztebl Int 2016; 113: 223.","journal-title":"Dtsch Arztebl Int"},{"key":"e_1_3_4_5_2","first-page":"370","article-title":"Sacroiliac joint dysfunction in patients with low back pain","volume":"36","author":"Barros G","year":"2019","unstructured":"Barros G, McGrath L, Gelfenbeyn M. Sacroiliac joint dysfunction in patients with low back pain. Fed Pract 2019; 36: 370.","journal-title":"Fed Pract"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10926-009-9164-5"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2016.1251"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e318270a12d"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.5045\/br.2016.51.1.3"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1302\/2058-5241.6.200017"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1159\/000477353"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/03635465231182438"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2020.01.003"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2015.08.005"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23031301"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1515\/sjpain-2018-0012"},{"key":"e_1_3_4_17_2","first-page":"1159","article-title":"Psychometric properties of chosen scales evaluating disability in low back pain-narrative review","volume":"12","author":"Chmielewski B","year":"2024","unstructured":"Chmielewski B, Wilski M. Psychometric properties of chosen scales evaluating disability in low back pain-narrative review. Healthcare (Basel) 2024; 12: 1159.","journal-title":"Healthcare (Basel)"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5928"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557"},{"key":"e_1_3_4_21_2","unstructured":"Jpt H. Cochrane handbook for systematic reviews of interventions. http:\/\/www cochrane-handbook org. 2008."},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-024-05153-5"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/papr.12544"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5558138"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.31616\/asj.2023.0115"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s43465-023-00898-3"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1177\/22104917231161836"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.4103\/ija.ija_821_22"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/papr.12526"},{"key":"e_1_3_4_30_2","first-page":"100011","article-title":"Effectiveness of intradiscal platelet rich plasma for discogenic low back pain without Modic changes: a randomized controlled trial","volume":"1","author":"Schepers MO","unstructured":"Schepers MO, Groot D, Kleinjan EM, et al. Effectiveness of intradiscal platelet rich plasma for discogenic low back pain without Modic changes: a randomized controlled trial. Interv Pain Med Mar 2022; 1: 100011.","journal-title":"Interv Pain Med"},{"key":"e_1_3_4_31_2","first-page":"35","article-title":"Platelet-Rich Plasma\u201d epidural injection an emerging strategy in lumbar disc herniation: a Randomized Controlled Trial","volume":"24","author":"Wongjarupong A","unstructured":"Wongjarupong A, Pairuchvej S, Laohapornsvan P, et al. Platelet-Rich Plasma\u201d epidural injection an emerging strategy in lumbar disc herniation: a Randomized Controlled Trial. BMC Musculoskelet Disord Apr 28 2023; 24: 35.","journal-title":"BMC Musculoskelet Disord"},{"key":"e_1_3_4_32_2","doi-asserted-by":"crossref","unstructured":"Akeda K Ohishi K Takegami N et al. Platelet-rich plasma releasate versus corticosteroid for the treatment of discogenic low back pain: a double-blind randomized controlled trial. J Clin Med 2022; 11: 304\u2013306.","DOI":"10.3390\/jcm11020304"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/papr.12893"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmrj.2015.08.010"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.15537\/smj.2022.43.11.20220449"},{"key":"e_1_3_4_36_2","article-title":"Effect of platelet-rich plasma injections for chronic nonspecific low back pain: a randomized controlled study","volume":"101","author":"Won SJ","unstructured":"Won SJ, Kim DY, Kim JM. Effect of platelet-rich plasma injections for chronic nonspecific low back pain: a randomized controlled study. Medicine (Baltimore) Feb 25 2022; 101: e28935.","journal-title":"Medicine (Baltimore)"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-023-01195-2"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.2016.1118458"},{"key":"e_1_3_4_39_2","first-page":"61","article-title":"Platelet-rich plasma (PRP) as a therapeutic agent: platelet biology, growth factors and a review of the literature","volume":"24","author":"Textor J","year":"2013","unstructured":"Textor J. Platelet-rich plasma (PRP) as a therapeutic agent: platelet biology, growth factors and a review of the literature. Platelet-Rich Plasma: Regener Med: Sports Med Orthopedic Recovery Musculoskeletal Injuries 2013; 24: 61\u201394.","journal-title":"Platelet-Rich Plasma: Regener Med: Sports Med Orthopedic Recovery Musculoskeletal Injuries"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2021.155560"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25147914"},{"key":"e_1_3_4_42_2","doi-asserted-by":"crossref","unstructured":"Flanagan GM Knab J Rothenberg J et al. Platelet-rich plasma. Essentials of regenerative medicine in interventional pain management. Pain Physician 2024; 22: 115\u2013131.","DOI":"10.1007\/978-3-031-50357-3_7"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1080\/14712598.2020.1798925"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnv053"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S444189"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.21037\/jss.2018.03.04"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2019.0292"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2012.04.148"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.3109\/09537104.2015.1116686"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1177\/23259671211011948"},{"key":"e_1_3_4_51_2","article-title":"Discussing the debate: leukocyte-rich platelet-rich plasma versus leukocyte-poor platelet-rich plasma","volume":"16","author":"Yadav S","year":"2024","unstructured":"Yadav S. Discussing the debate: leukocyte-rich platelet-rich plasma versus leukocyte-poor platelet-rich plasma. Cureus 2024; 16: e58381.","journal-title":"Cureus"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms262110804"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12010007"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-016-3178-3"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.21037\/jss.2018.03.04"},{"key":"e_1_3_4_56_2","first-page":"3S","article-title":"Growth factor content in PRP and their applicability in medicine","volume":"26","author":"Lubkowska A","year":"2012","unstructured":"Lubkowska A, Dolegowska B, Banfi G. Growth factor content in PRP and their applicability in medicine. J Biol Regul Homeost Agents 2012; 26: 3S\u201322S.","journal-title":"J Biol Regul Homeost Agents"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.5455\/mjhs.2019.01.009"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/boneres.2016.36"},{"key":"e_1_3_4_59_2","first-page":"39","article-title":"Augmenting tendon and ligament repair with platelet-rich plasma (PRP)","volume":"3","author":"Yuan T","year":"2013","unstructured":"Yuan T, Zhang C-Q, Wang JH. Augmenting tendon and ligament repair with platelet-rich plasma (PRP). Muscles Ligaments Tendons J 2013; 3: 39.","journal-title":"Muscles Ligaments Tendons J"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-010-1306-y"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2015.03.045"}],"container-title":["Journal of Back and Musculoskeletal Rehabilitation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10538127261448983","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10538127261448983","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10538127261448983","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:08:58Z","timestamp":1792840138000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10538127261448983"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,9]]},"references-count":60,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["10.1177\/10538127261448983"],"URL":"https:\/\/doi.org\/10.1177\/10538127261448983","relation":{},"ISSN":["1053-8127","1878-6324"],"issn-type":[{"value":"1053-8127","type":"print"},{"value":"1878-6324","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,9]]}}}