{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:37:42Z","timestamp":1792841862773,"version":"4.5.0"},"reference-count":35,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"the National Natural Science Foundation of China","award":["No.82074458"],"award-info":[{"award-number":["No.82074458"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"the National Natural Science Foundation of China","award":["No.82174411"],"award-info":[{"award-number":["No.82174411"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"the Natural Science Foundation of Jiangsu Province","award":["No.BK20220470"],"award-info":[{"award-number":["No.BK20220470"]}]},{"name":"the Natural Science Foundation of the Jiangsu Higher education Institution of China","award":["No.22KJB360012"],"award-info":[{"award-number":["No.22KJB360012"]}]},{"name":"the NATCM's Project of High-level Construction of Key TCM Disciplines","award":["NATCM's Human Education Letter[2023]No. 85"],"award-info":[{"award-number":["NATCM's Human Education Letter[2023]No. 85"]}]},{"name":"the Jiangsu CM Clinical Innovation Center of Degenerative Bone & Joint Disease","award":["Jiangsu science and education of traditional Chine"],"award-info":[{"award-number":["Jiangsu science and education of traditional Chine"]}]},{"name":"the Natural Science Foundation of Jiangsu Province","award":["No.BK20221351"],"award-info":[{"award-number":["No.BK20221351"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Back and Musculoskeletal Rehabilitation"],"published-print":{"date-parts":[[2026,11]]},"abstract":"\n Objective<\/jats:title>\n This study aimed to investigate the associations of multi-dimensional lipid metabolism indicators, comprising serum lipid profiles and the degree of fatty infiltration in the musculoskeletal system, with bone mineral density (BMD) and bone turnover markers (BTMs), and to identify independent risk factors for the occurrence and severity of osteoporotic vertebral compression fractures (OVCFs) in postmenopausal women.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This retrospective study included a total of 133 postmenopausal women from January 2023 to July 2024. Participants were stratified by fracture status and vertebral compression severity. Clinical data, including bone and lipid metabolic indicators and BMD, were retrieved from electronic medical records and MRI reanalysis. Pearson correlation analyzed associations between lipid metabolic indicators and BTMs\/BMD. Univariate and multivariate logistic regression analyses were performed to identify independent risk factors for OVCFs, with multicollinearity among variables assessed using the variance inflation factor (VIF), and ordinal logistic regression was applied to assess lipid metabolic indicators\u2019 impact on vertebral compression severity. Statistical analyses included Student's t-test or Mann-Whitney U test for group comparisons and one-way analysis of variance (ANOVA) for multiple-group comparisons.<\/jats:p>\n <\/jats:sec>\n \n Result<\/jats:title>\n \n This study included 133 participants: 34 controls, 32 with mild, 38 with moderate, and 29 with severe fractures. Age, BMI, BMD, vertebral bone quality (VBQ), the fatty infiltration ratio of the paraspinal muscles (FIR), and lipoprotein(a) [Lp(a)] differed significantly between fracture and control groups (all\n p<\/jats:italic>\n \u2009<\u20090.05). VBQ and FIR were negatively correlated with total BMD (r\u2009=\u2009-0.466,\n p<\/jats:italic>\n \u2009<\u20090.05; r\u2009=\u2009-0.455,\n p<\/jats:italic>\n \u2009<\u20090.05) and positively correlated with the ratio of the fractured vertebra compressed sagittal cross-sectional area (RCSA) (r\u2009=\u20090.344,\n p<\/jats:italic>\n \u2009<\u20090.05; r\u2009=\u20090.320,\n p<\/jats:italic>\n \u2009<\u20090.05) and age (r\u2009=\u20090.615,\n p<\/jats:italic>\n \u2009<\u20090.05; r\u2009=\u20090.283,\n p<\/jats:italic>\n \u2009<\u20090.05). Univariate and multivariate regression analyses indicated that VBQ (\n p<\/jats:italic>\n \u2009=\u20090.043; OR = 4.260, 95% CI: 1.046\u201317.345), FIR (\n p<\/jats:italic>\n \u2009=\u20090.047; OR = 2.372, 95% CI: 1.010\u20135.572), and Lp(a) (\n p<\/jats:italic>\n \u2009=\u20090.048; OR = 1.002, 95% CI: 1.002\u20131.799) were independently associated with an increased risk of OVCFs. Ordinal logistic regression confirmed VBQ (\n p<\/jats:italic>\n \u2009=\u20090.006; OR = 3.168, 95% CI: 1.378\u20137.282) and FIR (\n p<\/jats:italic>\n \u2009=\u20090.034; OR = 1.156, 95% CI: 1.009\u20131.325) were associated with increased fracture severity.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n VBQ and FIR were independently associated with osteoporotic fractures in postmenopausal women and were further linked to fracture severity, suggesting their potential value in risk stratification and fracture severity assessment. Although Lp(a) showed a statistically significant association with OVCFs, the association was relatively weak, and its clinical significance requires further validation.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/10538127261468079","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T10:42:07Z","timestamp":1783939327000},"page":"2121-2135","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of lipid metabolism and musculoskeletal fatty infiltration with the risk and severity of osteoporotic vertebral compression fractures in postmenopausal women: A retrospective study"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5103-2110","authenticated-orcid":false,"given":"Yihua","family":"Zhu","sequence":"first","affiliation":[{"name":"Laboratory of New Techniques of Restoration & Reconstruction, Institute of Traumatology & Orthopedics, Nanjing University of Chinese Medicine, Nanjing, 210023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1104-3821","authenticated-orcid":false,"given":"Qian","family":"Cheng","sequence":"additional","affiliation":[{"name":"Laboratory of New Techniques of Restoration & Reconstruction, Institute of Traumatology & Orthopedics, Nanjing University of Chinese Medicine, Nanjing, 210023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6826-4463","authenticated-orcid":false,"given":"Qitai","family":"Wu","sequence":"additional","affiliation":[{"name":"Laboratory of New Techniques of Restoration & Reconstruction, Institute of Traumatology & Orthopedics, Nanjing University of Chinese Medicine, Nanjing, 210023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3547-7880","authenticated-orcid":false,"given":"Jiaxin","family":"Liu","sequence":"additional","affiliation":[{"name":"Laboratory of New Techniques of Restoration & Reconstruction, Institute of Traumatology & Orthopedics, Nanjing University of Chinese Medicine, Nanjing, 210023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8146-8689","authenticated-orcid":false,"given":"Wumiti","family":"Taxi","sequence":"additional","affiliation":[{"name":"Laboratory of New Techniques of Restoration & Reconstruction, Institute of Traumatology & Orthopedics, Nanjing University of Chinese Medicine, Nanjing, 210023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4489-1925","authenticated-orcid":false,"given":"Tianchi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Laboratory of New Techniques of Restoration & Reconstruction, Institute of Traumatology & Orthopedics, Nanjing University of Chinese Medicine, Nanjing, 210023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1334-8519","authenticated-orcid":false,"given":"Qinfeng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Laboratory of New Techniques of Restoration & Reconstruction, Institute of Traumatology & Orthopedics, Nanjing University of Chinese Medicine, Nanjing, 210023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9649-8142","authenticated-orcid":false,"given":"Kaixuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory of New Techniques of Restoration & Reconstruction, Institute of Traumatology & Orthopedics, Nanjing University of Chinese Medicine, Nanjing, 210023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0805-079X","authenticated-orcid":false,"given":"Xi","family":"Chen","sequence":"additional","affiliation":[{"name":"Laboratory of New Techniques of Restoration & Reconstruction, Institute of Traumatology & Orthopedics, Nanjing University of Chinese Medicine, Nanjing, 210023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3932-5867","authenticated-orcid":false,"given":"Cong","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory of New Techniques of Restoration & Reconstruction, Institute of Traumatology & Orthopedics, Nanjing University of Chinese Medicine, Nanjing, 210023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4615-6978","authenticated-orcid":false,"given":"Yang","family":"Guo","sequence":"additional","affiliation":[{"name":"Laboratory of New Techniques of Restoration & Reconstruction, Institute of Traumatology & Orthopedics, Nanjing University of Chinese Medicine, Nanjing, 210023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2773-2001","authenticated-orcid":false,"given":"Yong","family":"Ma","sequence":"additional","affiliation":[{"name":"Laboratory of New Techniques of Restoration & Reconstruction, Institute of Traumatology & Orthopedics, Nanjing University of Chinese Medicine, Nanjing, 210023, China"},{"name":"School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China"},{"name":"Jiangsu CM Clinical Innovation Center of Degenerative Bone & Joint Disease, Wuxi TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Wuxi, 214072, China"},{"name":"Yancheng TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Yancheng, 224001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6287-5724","authenticated-orcid":false,"given":"Lining","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory of New Techniques of Restoration & Reconstruction, Institute of Traumatology & Orthopedics, Nanjing University of Chinese Medicine, Nanjing, 210023, China"},{"name":"School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China"},{"name":"Department of Traumatology and Orthopedics, Nanjing hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, 210023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,13]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2024.08.008"},{"key":"e_1_3_3_3_2","first-page":"345","article-title":"Diagnosis and management of osteoporotic vertebral compression fractures","volume":"108","author":"Daher M","year":"2026","unstructured":"Daher M, Sebaaly A, Sakr I, et al. Diagnosis and management of osteoporotic vertebral compression fractures. The Journal of Bone and Joint Surgery American Volume 2026; 108: 345\u2013354.","journal-title":"The Journal of Bone and Joint Surgery American Volume"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.5312\/wjo.v13.i6.564"},{"key":"e_1_3_3_5_2","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.eprac.2021.12.011","article-title":"The risk factors for developing clustered vertebral compression fractures: a single-center study","volume":"28","author":"Wang X","year":"2022","unstructured":"Wang X, Jiang J, Guan W, et al. The risk factors for developing clustered vertebral compression fractures: a single-center study. Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 2022; 28: 243\u2013249.","journal-title":"Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-021-01283-6"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2024.117072"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3895"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2024.1406046"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-023-06640-2"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.21037\/qims-23-1770"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-70178-3_12"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/os.13531"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2025.01.016"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650080915"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/10538127251340350"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-025-06359-x"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20110380"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0000000000001154"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.3233\/BMR-220059"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2021.07.020"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.3171\/2019.9.SPINE19954"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bonr.2023.101711"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2023.11.007"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.21106"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.27154"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-026-06848-7"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2025.2373"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2023.101122"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2018-00138"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-023-07912-0"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-021-06147-3"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.1073013"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2025.02.030"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/os.70098"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2021.03.028"}],"container-title":["Journal of Back and Musculoskeletal Rehabilitation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10538127261468079","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10538127261468079","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10538127261468079","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:04:10Z","timestamp":1792839850000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10538127261468079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,13]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["10.1177\/10538127261468079"],"URL":"https:\/\/doi.org\/10.1177\/10538127261468079","relation":{},"ISSN":["1053-8127","1878-6324"],"issn-type":[{"value":"1053-8127","type":"print"},{"value":"1878-6324","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,13]]}}}