{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:18:16Z","timestamp":1790705896374,"version":"4.1.0"},"reference-count":18,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:00:00Z","timestamp":1737417600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100023835","name":"NIH Brain Initiative","doi-asserted-by":"crossref","award":["1UH3 NS095554-01"],"award-info":[{"award-number":["1UH3 NS095554-01"]}],"id":[{"id":"10.13039\/100023835","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100023835","name":"NIH Brain Initiative","doi-asserted-by":"crossref","award":["1RF1MH12378-01"],"award-info":[{"award-number":["1RF1MH12378-01"]}],"id":[{"id":"10.13039\/100023835","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["NeuroRehabilitation: An International, Interdisciplinary Journal"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Studies of moderate-to-severe traumatic brain injury (TBI) report persistent clinical impairment post-injury. In the CENTURY-S study of deep brain stimulation (DBS) in chronic TBI, Schiff et al.\u2018s paper, \u201cThalamic deep brain stimulation in traumatic brain injury: a phase 1, randomized feasibility study\u201d demonstrated improvements in executive control. A companion narrative analysis by Fins et al., \u201cSubject and Family Perspectives from the Central Thalamic Deep Brain Stimulation Trial for Traumatic Brain Injury\u201d Parts I and II described improvements in cognitive, behavioral, and emotional capabilities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The present study provides an aggregate symptom assessment utilizing pre- and post-DBS narratives from subjects and their family members.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Drawing upon participants from the CENTURY-S study, Fins et al. conducted semi-structured interviews with five subjects with moderate-to-severe TBI and their family members. Transcripts were subsequently coded deductively and inductively in Dedoose by two independent investigators.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Subjects and families frequently volunteered memory and cognitive symptoms as well as difficulties with self-regulation, frustration, and irritability pre-DBS. Following stimulation, four subjects and four families noted improvement in memory and attention and focus, while three subjects and five families volunteered improvements in self-regulation. Fatigue improved in three subjects who previously reported this symptom and in one who did not.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Secondary qualitative analysis of narrative data of DBS trial participants supports the incorporation of qualitative data as additional outcome measures in studies of DBS in TBI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10538135241296732","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T04:36:12Z","timestamp":1737434172000},"page":"143-151","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Qualitative Analysis of Symptoms from the Central Thalamic Deep Brain Stimulation Trial for Traumatic Brain Injury"],"prefix":"10.1177","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0081-3338","authenticated-orcid":false,"given":"Linda M","family":"Gerber","sequence":"first","affiliation":[{"name":"Department of Population Health Sciences, Weill Cornell Medical College, NY, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiulani S","family":"Shulman","sequence":"additional","affiliation":[{"name":"Division of Medical Ethics, Weill Cornell Medical College, NY, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan S","family":"Wright","sequence":"additional","affiliation":[{"name":"Division of Medical Ethics, Weill Cornell Medical College, NY, NY, USA"},{"name":"College of Law, College of Medicine, Penn State University, University Park, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas D","family":"Schiff","sequence":"additional","affiliation":[{"name":"Feil Family Brain and Mind Research Institute, Weill Cornell Medical College, NY, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7221-0053","authenticated-orcid":false,"given":"Joseph J","family":"Fins","sequence":"additional","affiliation":[{"name":"Division of Medical Ethics, Weill Cornell Medical College, NY, NY, USA"},{"name":"Solomon Center for Health Law and Policy, Yale Law School, New Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,1,21]]},"reference":[{"key":"e_1_3_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psc.2013.12.001"},{"key":"e_1_3_5_3_1","unstructured":"Campbell M. (May 12 2017). Measuring How Patients Feel and Function. Presented at \u201cRoadmap to Engaging CDER Public Workshop\u201d. U.S. Food & Drug Administration. Silver Spring Maryland. Accessed 3 July 2024. https:\/\/www.fda.gov\/media\/104969\/download"},{"key":"e_1_3_5_4_1","unstructured":"Center for Drug Evaluation and Research (CDER) in cooperation with the Center for Biologics Evaluation and Research (CBER) and the Center for Devices and Radiological Health (CDRH) at the Food and Drug Administration. (December 2009). Guidance for Industry Patient-Reported Outcome Measures: Use in Medical Product Development to Support Labeling Claims. 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