{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T09:21:45Z","timestamp":1782984105513,"version":"3.54.5"},"reference-count":31,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T00:00:00Z","timestamp":1740009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["NeuroRehabilitation: An International, Interdisciplinary Journal"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients with Multiple Sclerosis (PwMS) have gait disorders. The efficiency of treadmill training on walking distance is debatable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      This study evaluated the efficacy of a 6-week treadmill training program at heart rate at the first ventilatory threshold (HR\n                      <jats:sub>VT1<\/jats:sub>\n                      ) on walking distance compared with a control group in PwMS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This prospective, multicenter study included 46 PwMS with moderate disability which randomized into training group (TG) and control group (CG). Patients performed cardiopulmonary exercise test to determine HR\n                      <jats:sub>VT1<\/jats:sub>\n                      . TG realized walking treadmill training program at HR\n                      <jats:sub>VT1<\/jats:sub>\n                      : 18 sessions (3 sessions\/week) over 6 weeks. The distance on the six-minute walk test (6MWT), Timed 25 foot walk, patient-reported walking ability, berg balance scale, fatigue scale, the HR at the end of the 6MWT (HR\n                      <jats:sub>6MWT<\/jats:sub>\n                      ) were collected at baseline, 6 weeks and 12 weeks.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The 6MWT distance showed a significant overall group effect (30.6 m; 95%CI\u2009=\u2009(6.6; 54.6);\n                      <jats:italic>p\u2009<\/jats:italic>\n                      =\u20090.017). The perceived impact of walking was significantly decreased in the TG (\u22126.1; 95% CI\u2009=\u2009(\u22129.2; \u22122.9); p\u2009=\u20090.0006). No correlation was found between HR\n                      <jats:sub>VT1<\/jats:sub>\n                      and HR\n                      <jats:sub>6MWT<\/jats:sub>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Aerobic treadmill training significantly enhanced walking distance and reduced perceived walking difficulties in PwMS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10538135241306674","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T03:18:06Z","timestamp":1740021486000},"page":"243-253","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Effectiveness of Aerobic Treadmill Training on Walking Distance in Patients with Multiple Sclerosis with Moderate Disability: A Randomised Controlled Multicentre Trial"],"prefix":"10.1177","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6246-4749","authenticated-orcid":false,"given":"C","family":"Massot","sequence":"first","affiliation":[{"name":"Service de M\u00e9decine Physique et de R\u00e9adaptation, 249 rue du Grand But, 59462 Lomme Cedex, France"},{"name":"ETHICS, (EA7446), Universit\u00e9 Catholique de Lille, FLSH, Lille, France"},{"name":"UPHF, LAMIH, F-59313 Valenciennes, France"},{"name":"CNRS, UMR 8201, F-59313 Valenciennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MA","family":"Guyot","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Physique et de R\u00e9adaptation, 249 rue du Grand But, 59462 Lomme Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Blanchard","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Physique et de R\u00e9adaptation Affections Neurologiques Chroniques, CHU de Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Norberciak","sequence":"additional","affiliation":[{"name":"Service de la Direction de la Recherche Clinique, 249 rue du Grand But, 59462 Lomme Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Donze","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Physique et de R\u00e9adaptation, 249 rue du Grand But, 59462 Lomme Cedex, France"},{"name":"ETHICS, (EA7446), Universit\u00e9 Catholique de Lille, FLSH, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,2,20]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.5812\/ircmj.3597"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/1545968314521010"},{"issue":"2","key":"e_1_3_4_4_1","article-title":"Measuring balance in the elderly\u202f: Validation of an instrument","volume":"83","author":"Berg K. 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