{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:23:06Z","timestamp":1792041786237,"version":"4.4.0"},"reference-count":38,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Clinical research project of Shanghai Municipal Health Commission\u2080","award":["202240379"],"award-info":[{"award-number":["202240379"]}]},{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of china","doi-asserted-by":"crossref","award":["82102647"],"award-info":[{"award-number":["82102647"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["NeuroRehabilitation: An International, Interdisciplinary Journal"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pathological upper-limb synergistic movement is a prevalent symptom of post-stroke motor dysfunction and pose a significant challenge in the rehabilitation of hemiplegia. However, the underlying mechanisms remain elusive, hindering the development of effective therapeutic strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to explore the mechanisms underlying pathological synergic movements post-stroke by examining the interrelationship between motor modules associated with upper limb flexion synergy and the repetitive action of \u201ctaking food to the mouth.\u201d<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Surface electromyography (sEMG) was employed to capture the EMG signals of normal elbow flexion, the act of \u201ctaking food to the mouth,\u201d and post-stroke upper limb flexion synergy. Non-negative matrix factorization (NMF) was employed to compare and analyze the corresponding modular and coefficient matrices derived from these three motor tasks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The modular matrix associated with flexion synergy exhibited the most significant correlation with the \u201ctaking food to the mouth\u201d task, whereas the coefficient matrix shared the lowest correlation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Upper limb flexion synergy after stroke may be related to the activation of the highly excitatory motor module formed by previously repeated movement of \u201ctaking food to mouth\u201d.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10538135251315378","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T03:07:38Z","timestamp":1740539258000},"page":"384-393","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Taking Food to Mouth: Correlation Between Repetitive Movement and Upper Limb Flexion Synergy After Stroke"],"prefix":"10.1177","volume":"56","author":[{"given":"Gang","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin-hsuan","family":"Chia","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-jun","family":"Jia","sequence":"additional","affiliation":[{"name":"The Center for Biomedical Engineering, School of Information Science and Technology, Fudan University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-xi","family":"Chen","sequence":"additional","affiliation":[{"name":"The Center for Biomedical Engineering, School of Information Science and Technology, Fudan University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-ning","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-fa","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cui-wei","family":"Yang","sequence":"additional","affiliation":[{"name":"The Center for Biomedical Engineering, School of Information Science and Technology, Fudan University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,2,26]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00813.2016"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncom.2017.00078"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00472.2019"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2007.08.004"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0910114106"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2552\/ab8e8e"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0500199102"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1010"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP277018"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1210617"},{"key":"e_1_3_2_12_1","first-page":"1","article-title":"A systematic review on muscle synergies: From building blocks of motor behavior to a neurorehabilitation tool","volume":"2018","author":"Emanuel S. 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