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Fatigue is another highly prevalent NMS. Presence of both is detrimental for the individual's well-being, but their association remains largely unexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess the relationship between pain, fatigue, and mediating variables in PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fifty-three PD patients with pain participated in a cross-sectional study. Correlation analyses were performed between clinical, self-reported measures of pain (Spanish-King's-Parkinson-Pain-Scale (S-KPPS) and Brief-Pain-Inventory (BPI) and fatigue (Fatigue-Severity-Scale (FSS), Daily-Fatigue-Impact-Scale (DFIS)). Partial correlations were performed considering these confounders: Levodopa-equivalent daily dose (LEDD), years from PD diagnosis, UPDRS-III score, anxiety, depression and kinesiophobia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fatigue severity (FSS) was positively and moderately correlated with pain interference (BPI; \u03c1\u2009=\u20090.351, p\u2009=\u20090.045) and symptomatic burden (S-KPPS; \u03c1\u2009=\u20090.367, p\u2009=\u20090.042), but not intensity (BPI; \u03c1\u2009=\u20090.122, p\u2009=\u20090.446). DFIS did not correlate with any dimension of pain (p\u2009&gt;\u20090.05). Motor symptoms, anxiety, depression and kinesiophobia changed correlation significance, but LEDD and disease duration didn\u2019t.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A moderate correlation was found between fatigue severity and both pain interference and symptomatic burden, influenced by other non-motor symptoms (NMS) like anxiety and depression. Although anxiety and depression have previously been associated with fatigue, this study adds pain to a tetrad of interrelated NMS prevalent in PD<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10538135251325761","type":"journal-article","created":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T18:17:49Z","timestamp":1742494669000},"page":"549-559","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Pain and Fatigue in Parkinson\u2019s Disease: Exploring Their Interrelation and Mediating Variables"],"prefix":"10.1177","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1927-979X","authenticated-orcid":false,"given":"Alfonso","family":"Hurtado-Mart\u00ednez","sequence":"first","affiliation":[{"name":"Escuela Internacional de Doctorado, Universidad Francisco de Vitoria, Pozuelo de Alarc\u00f3n, Spain"},{"name":"Brain Injury and Movement Disorders Neurorehabilitation Group (GINDAT), Universidad Francisco de Vitoria, Pozuelo de Alarc\u00f3n, 28223, Spain"},{"name":"Facultad de Ciencias Experimentales, Universidad Francisco de Vitoria, Pozuelo de Alarc\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3819-3090","authenticated-orcid":false,"given":"Yeray","family":"Gonz\u00e1lez-Zamorano","sequence":"additional","affiliation":[{"name":"Brain Injury and Movement Disorders Neurorehabilitation Group (GINDAT), Universidad Francisco de Vitoria, Pozuelo de Alarc\u00f3n, 28223, Spain"},{"name":"Escuela Internacional de Doctorado, Department of Physical Therapy, Occupational Therapy, Rehabilitation and Physical Medicine, Universidad Rey Juan Carlos, 28933 Alcorc\u00f3n, Spain"},{"name":"Department of Physical Therapy, Occupational Therapy, Rehabilitation and Physical Medicine, Universidad Rey Juan Carlos, Alcorc\u00f3n, Spain"},{"name":"Cognitive Neuroscience, Pain and Rehabilitation Research Group (NECODOR), Faculty of Health Sciences, Rey Juan Carlos University, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9726-8518","authenticated-orcid":false,"given":"Marcos","family":"Moreno-Verd\u00fa","sequence":"additional","affiliation":[{"name":"Brain Injury and Movement Disorders Neurorehabilitation Group (GINDAT), Universidad Francisco de Vitoria, Pozuelo de Alarc\u00f3n, 28223, Spain"},{"name":"Brain, Action, and Skill Laboratory (BAS-Lab), Institute of Neuroscience (Cognition and Systems division), UC Louvain, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6202-7071","authenticated-orcid":false,"given":"Francisco Jos\u00e9","family":"S\u00e1nchez-Cuesta","sequence":"additional","affiliation":[{"name":"Brain Injury and Movement Disorders Neurorehabilitation Group (GINDAT), Universidad Francisco de Vitoria, Pozuelo de Alarc\u00f3n, 28223, Spain"},{"name":"Facultad de Ciencias Experimentales, Universidad Francisco de Vitoria, Pozuelo de Alarc\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1314-624X","authenticated-orcid":false,"given":"Josu\u00e9 Fernandez","family":"Carnero","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, Occupational Therapy, Rehabilitation and Physical Medicine, Universidad Rey Juan Carlos, Alcorc\u00f3n, Spain"},{"name":"Cognitive Neuroscience, Pain and Rehabilitation Research Group (NECODOR), Faculty of Health Sciences, Rey Juan Carlos University, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3190-1296","authenticated-orcid":false,"given":"Juan Pablo","family":"Romero","sequence":"additional","affiliation":[{"name":"Brain Injury and Movement Disorders Neurorehabilitation Group (GINDAT), Universidad Francisco de Vitoria, Pozuelo de Alarc\u00f3n, 28223, Spain"},{"name":"Facultad de Ciencias Experimentales, Universidad Francisco de Vitoria, Pozuelo de Alarc\u00f3n, Spain"},{"name":"Brain Damage Unit, Beata Mar\u00eda Ana Hospital, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,3,20]]},"reference":[{"issue":"6","key":"e_1_3_3_2_1","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1037\/hea0000611","article-title":"Cognitive and affective mechanisms of pain and fatigue in multiple sclerosis","volume":"37","author":"Arewasikporn A.","year":"2018","unstructured":"Arewasikporn A., Turner A. 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