{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T20:48:48Z","timestamp":1782074928175,"version":"3.54.5"},"reference-count":20,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100005357","name":"Agent\u00fara na Podporu V\u00fdskumu a V\u00fdvoja","doi-asserted-by":"publisher","award":["24-0369"],"award-info":[{"award-number":["24-0369"]}],"id":[{"id":"10.13039\/501100005357","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007594","name":"Univerzita Komensk\u00e9ho v Bratislave","doi-asserted-by":"publisher","award":["1013\/2025"],"award-info":[{"award-number":["1013\/2025"]}],"id":[{"id":"10.13039\/100007594","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["NeuroRehabilitation"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:p>\n                    Exercise is increasingly recognized as a key component of Parkinson's disease (PD) management, but data on short-term combined aerobic-resistance training (ART) on motor and metabolic parameters remain limited. In this controlled study, 28 patients with PD (median Hoehn &amp; Yahr stage= 2, IQR 1.75-2.0) were allocated to an 8-week supervised ART group (n= 19) or a stretching-only control group (n = 9). Training consisted of two 45-minute sessions weekly. Primary outcomes were MDS-UPDRS-III, Sit-to-Stand Test (STS), and Six-Minute Walk Test (6MWT). Fasting laboratory parameters were exploratory given the small sample size and absence of an a priori power analysis. Between-group post-intervention differences were analyzed using ANCOVA (baseline as covariate); exploratory biochemical outcomes were controlled for multiple comparisons using Benjamini-Hochberg false discovery rate (FDR). ART improved the MDS-UPDRS-III tremor subscore (p = 0.004) and6MWT distance (p = 0.003), with no significant effects on other motor or functional outcomes. In exploratory laboratory analyses, unadjusted between-group differences were observed for HDL cholesterol (p =0.014), vitamin D\n                    <jats:sub>3<\/jats:sub>\n                    (p = 0.003), TSH (p = 0.042), and homocysteine (p =0.019); after FDR correction, only vitamin D\n                    <jats:sub>3<\/jats:sub>\n                    remained significant (qFDR= 0.039). Total cholesterol, LDL, and VLDL showed non-significant decreases. An eight-week ART program improved tremor and walking endurance inpatients with PD, while other motor outcomes remained unchanged. Exploratory changes in selected biochemical markers were detected (including a decrease in vitamin D\n                    <jats:sub>3<\/jats:sub>\n                    ); their clinical relevance remains unclear and should be evaluated in larger, well-powered randomized studies.\n                  <\/jats:p>","DOI":"10.1177\/10538135261434253","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T13:14:22Z","timestamp":1775826862000},"page":"659-667","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of an 8-Week Combined Aerobic-Resistance Training on Motor Function, Functional Mobility, and Metabolic Parameters in Patients with Parkinson's Disease: A Controlled Study"],"prefix":"10.1177","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6459-1768","authenticated-orcid":false,"given":"\u0160imon","family":"Janovi\u010d","sequence":"first","affiliation":[{"name":"2nd Department of Neurology, Faculty of Medicine, Comenius University and University Hospital Bratislava, Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Szabo","sequence":"additional","affiliation":[{"name":"Clinic of Physical Medicine, Balneology and Medical Rehabilitation, Slovak Medical University and University Hospital Bratislava, Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"G\u00e1bor","sequence":"additional","affiliation":[{"name":"2nd Department of Neurology, Faculty of Medicine, Comenius University and University Hospital Bratislava, Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Straka","sequence":"additional","affiliation":[{"name":"2nd Department of Neurology, Faculty of Medicine, Comenius University and University Hospital Bratislava, Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zita","family":"Majern\u00edkov\u00e1","sequence":"additional","affiliation":[{"name":"Clinic of Physical Medicine, Balneology and Medical Rehabilitation, Slovak Medical University and University Hospital Bratislava, Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Ku\u0161n\u00edrov\u00e1","sequence":"additional","affiliation":[{"name":"2nd Department of Neurology, Faculty of Medicine, Comenius University and University Hospital Bratislava, Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika","family":"Bolekov\u00e1","sequence":"additional","affiliation":[{"name":"2nd Department of Neurology, Faculty of Medicine, Comenius University and University Hospital Bratislava, Bratislava, Slovakia"},{"name":"Faculty of Psychology, Institute of Clinical Psychology, Pan-European University, Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuzana","family":"Ko\u0161utzk\u00e1","sequence":"additional","affiliation":[{"name":"2nd Department of Neurology, Faculty of Medicine, Comenius University and University Hospital Bratislava, Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,10]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318225ab66"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/geriatrics9040094"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25380"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.5334\/tohm.599"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2008.01.013"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22340"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.17.1.107"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.23251"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61393-3"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-024-02200-2"},{"key":"e_1_3_3_12_1","unstructured":"Keus S. Munneke M. Graziano M. Paltamaa J. Pelosin E. Domingos J. Ramaswamy B. Prins J. Struiksma C. Rochester L. Nieuwboer A. Bloem B. (2014). European physiotherapy guideline for Parkinson\u2019s disease."},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020194"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-021-00193-8"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-024-04317-9"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2015.11.028"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/sms.12581"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26424"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2017.3517"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.646"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S231359"}],"container-title":["NeuroRehabilitation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10538135261434253","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10538135261434253","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10538135261434253","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T20:20:27Z","timestamp":1782073227000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10538135261434253"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,10]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1177\/10538135261434253"],"URL":"https:\/\/doi.org\/10.1177\/10538135261434253","relation":{},"ISSN":["1053-8135","1878-6448"],"issn-type":[{"value":"1053-8135","type":"print"},{"value":"1878-6448","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,10]]}}}