{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T20:48:48Z","timestamp":1782074928715,"version":"3.54.5"},"reference-count":20,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["NeuroRehabilitation"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The longitudinal effects of combining intensive speech therapy (ST) with two separate courses of high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) for aphasia remain unclear. This study retrospectively investigated longitudinal changes in language function in patients who underwent this combined protocol.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sixteen patients with chronic aphasia underwent two courses of 2-week inpatient treatment combining fMRI-guided HF-rTMS and intensive ST between April 2018 and February 2025. The Standard Language Test of Aphasia (SLTA) total and modality-specific raw scores were assessed at four time points: at the 1st admission, 3 months after the 1st discharge, at the 2nd admission, and 3 months after the 2nd discharge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean SLTA total raw score significantly improved over time: 147\u2009\u00b1\u200951.6 at the 1st admission, 157\u2009\u00b1\u200949.9 at 3 months after the 1\n                      <jats:sup>st<\/jats:sup>\n                      discharge, 159\u2009\u00b1\u200948.8 at the 2nd admission, and 163\u2009\u00b1\u200950.2 at 3 months after the 2nd discharge. Significant improvements in speech function were observed in the Overall, Fluent Aphasia, and Non-fluent Aphasia groups. Notably, therapeutic effects were maintained without decline between the two admissions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Two courses of HF-rTMS combined with intensive ST may be effective for the long-term improvement of language function, particularly speech function, in patients with chronic aphasia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10538135261439938","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T14:05:11Z","timestamp":1775743511000},"page":"651-658","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Retrospective Study on the Effects of Intensive Speech Therapy Combined with Two Courses of High-Frequency rTMS on Language Function in Patients with Aphasia"],"prefix":"10.1177","volume":"58","author":[{"given":"Minori","family":"Yamada","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensuke","family":"Ohara","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuina","family":"Koutou","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhide","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuo","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8077-5130","authenticated-orcid":false,"given":"Sin","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1121-9339","authenticated-orcid":false,"given":"Kentaro","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6701-4974","authenticated-orcid":false,"given":"Masahiro","family":"Abo","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,9]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000338773"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2009.09.020"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2021.105855"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11101853"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/01616412.2018.1453980"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/02699052.2010.494587"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rehab.2015.05.006"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2019.11.002"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000213424"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-2457(99)00323-5"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandl.2004.08.004"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.2490\/jjrmc.23048"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.3233\/NRE-210139"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.2496\/hbfr.35.344"},{"key":"e_1_3_3_16_1","first-page":"4589056","article-title":"The effect of rTMS over the different targets on language recovery in stroke patients with global aphasia: A randomized sham-controlled study","volume":"29","author":"Ren C.","year":"2019","unstructured":"Ren C., Zhang G., Xu X., Hao J., Fang H., Chen P., Li Z., Ji Y., Cai Q., Gao F. 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