{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T11:36:51Z","timestamp":1786534611365,"version":"build-2736575974"},"reference-count":15,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19K19623"],"award-info":[{"award-number":["19K19623"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["NeuroRehabilitation"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hand edema is a common post-stroke complication that negatively affects function and quality of life. However, interventions for hand edema remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>In this study, we investigated whether contralateral resistance handgrip exercises performed with the non-paretic hand could immediately and sustainably reduce hand edema in patients with stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study used a B\u2013A\u2013B single-case design to explore the effects of the intervention in inpatients more than 3 months post-stroke. During the two 8-day intervention phases, the participants performed rhythmic handgrip exercises at 30% of the maximum voluntary contraction for 5\u2005min daily as part of their occupational therapy sessions. A baseline phase without intervention was interposed. The hand volume was measured by using water displacement before and after exercise sessions to assess immediate and sustained effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Four inpatients with paretic hand edema (93\u2013110 days poststroke) participated in this study. Contralateral handgrip exercise resulted in immediate reduction in paretic hand edema in three of the four patients; however, only one patient showed a sustained effect. The intervention was simple and feasible, with responses varying across individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This small single-case study suggests that contralateral handgrip exercise may contribute to reducing hand edema in some patients; however, its sustained benefits remain uncertain. This low-cost approach may serve as a candidate adjunct intervention in rehabilitation, particularly when paretic limb movements are limited. However, given the exploratory nature of this small single-case study, further investigation with larger samples and more rigorous designs is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10538135261462561","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T19:08:14Z","timestamp":1782846494000},"page":"119-125","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Immediate and Sustained Effects of Contralateral Handgrip Exercise on Hand Edema in Patients with Stroke"],"prefix":"10.1177","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7590-6419","authenticated-orcid":false,"given":"Hiroyuki","family":"Hayashi","sequence":"first","affiliation":[{"name":"Faculty of Care and Rehabilitation, Seijoh University, Tokai, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayana","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Tokai Memorial Hospital, Kasugai, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Tomiyama","sequence":"additional","affiliation":[{"name":"Faculty of Care and Rehabilitation, Seijoh University, Tokai, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hibiki","family":"Ogihara","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Tokai Memorial Hospital, Kasugai, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1191\/0269215505cr846oa"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-023-03054-4"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/17474930241308142"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.2340\/16501977-0780"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hkjot.2016.03.002"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.5014\/ajot.2016.017939"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.5014\/ajot.2014.009423"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.3400\/avd.oa.20-00024"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/10538135251336060"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13237"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1076029619832111"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jht.2025.12.005"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/28.1.9"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0029312"},{"issue":"1","key":"e_1_3_3_16_1","article-title":"Peripheral vasoreactivity in acute ischemic stroke with hemiplegia","volume":"11","author":"Wang S. 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Scientific Reports, 11(1), Article 8531. https:\/\/doi.org\/10.1038\/s41598-021-88050-9","journal-title":"Scientific Reports"}],"container-title":["NeuroRehabilitation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10538135261462561","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10538135261462561","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10538135261462561","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T11:03:45Z","timestamp":1786532625000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10538135261462561"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,30]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1177\/10538135261462561"],"URL":"https:\/\/doi.org\/10.1177\/10538135261462561","relation":{},"ISSN":["1053-8135","1878-6448"],"issn-type":[{"value":"1053-8135","type":"print"},{"value":"1878-6448","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,30]]}}}