{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T13:37:20Z","timestamp":1793367440811,"version":"4.5.0"},"reference-count":44,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["NeuroRehabilitation"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Current neurorehabilitation often relies on static, diagnosis-driven protocols or generic exercise administration, contributing to suboptimal long-term outcomes. There is a clinical need for a cohesive, mechanism-based framework to guide therapeutic reasoning, dosing, and longitudinal adaptation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A scoping review of neurorehabilitation literature was conducted according to PRISMA-ScR guidelines to map evidence on dosing, intensity, and longitudinal management. From 9,373 records, 42 studies were synthesized. The literature did not converge on standardized dosing parameters but supported a broad distinction between higher-intensity approaches for non-progressive conditions and more conservative, energy-conserving strategies for progressive conditions. Integrating these findings with author consensus, we developed a collaborative viewpoint proposing a hypothesis-generating clinical framework.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Proposed Framework<\/jats:title>\n                    <jats:p>We conceptualize three dynamic clinical pillars: (1) Optimization of Motor Performance, targeting behavioral restitution of activities of daily living through experience-dependent neuroplasticity; (2) Maximization of Motor Performance, promoting active neuroprotection in early degenerative diseases and structural compensation in stable lesions through high physiological effort; and (3) Preservation of Remaining Functions, prioritizing energy conservation and reduction of secondary sequelae in rapidly progressive conditions. The evidence supports the broad progressive versus non-progressive dosing distinction, while the three-pillar structure, FITT-PRO profiles, and transition triggers remain hypotheses requiring validation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Application<\/jats:title>\n                    <jats:p>A preliminary decision-support structure is proposed around FITT-PRO parameters and longitudinal reassessment. Transition triggers, such as biological plateaus or exacerbations, are not yet operationally defined and require prospective biomarker-based validation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This framework differentiates conditions by functional responsiveness rather than diagnosis, supporting interdisciplinary prognostic reasoning while requiring prospective validation before clinical implementation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10538135261470437","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T13:40:22Z","timestamp":1786974022000},"page":"364-377","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Beyond the Diagnosis: An Integrated Perspective on Strategic Dosing in Neurologic Motor Rehabilitation. A Scoping Review and Collaborative Viewpoint"],"prefix":"10.1177","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4719-890X","authenticated-orcid":false,"given":"Ahmad","family":"Rifai Sarraj","sequence":"first","affiliation":[{"name":"Lebanese University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6735-2648","authenticated-orcid":false,"given":"Jihan","family":"Allaw","sequence":"additional","affiliation":[{"name":"Lebanese University"},{"name":"Universit\u00e9 Polytechnique Hauts-De-France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2051-732X","authenticated-orcid":false,"given":"Fadi","family":"Zein El Abidin","sequence":"additional","affiliation":[{"name":"Neurophysiotherapy Department, Spine Care Center, Beirut, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7623-237X","authenticated-orcid":false,"given":"Antonio","family":"Pinti","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Polytechnique Hauts-De-France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcab233"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2026.1692088"},{"issue":"3","key":"e_1_3_3_4_1","article-title":"Consideration of Dose and Timing When Applying Interventions After Stroke and Spinal Cord Injury","volume":"41","author":"Basso D. 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