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The purpose of this secondary data analysis was to explore associations of those factors with three empirically verified measures of HF-related clinical, physical, and mental health status. Baseline data of 198 advanced systolic HF (EF\u2009&lt;\u200940%) patients were analyzed. Patients were 61.6% male, with a mean age of 62.3 ( SD\u2009=\u200913.2) years. The multivariable general linear modeling results indicated that patients who had poorer scores on HF-related clinical status were those who had sleep apnea ( \u03b2\u2009=\u2009\u22126.6, p\u2009&lt;\u2009.05), daytime sleepiness ( \u03b2\u2009=\u2009\u22129.4, p\u2009&lt;\u2009.01), four or more comorbidities ( \u03b2\u2009=\u2009\u221211.8, p\u2009&lt;\u2009.001), and depression ( \u03b2\u2009=\u2009\u221218.7, p\u2009&lt;\u2009.001). Depression was associated with all three measures of HF-related health status. These findings alert nurses to assess for sleep apnea and to use known screening measures for daytime sleepiness, depression, and comorbidities.<\/jats:p>","DOI":"10.1177\/10547738211015545","type":"journal-article","created":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T09:08:10Z","timestamp":1620810490000},"page":"1222-1230","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Impact of Sleep Apnea, Daytime Sleepiness, Comorbidities, and Depression on Patients\u2019 Heart Failure Health Status"],"prefix":"10.1177","volume":"30","author":[{"given":"Ubolrat","family":"Piamjariyakul","sequence":"first","affiliation":[{"name":"West Virginia University, Morgantown, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1590-9810","authenticated-orcid":false,"given":"April L.","family":"Shapiro","sequence":"additional","affiliation":[{"name":"West Virginia University, Keyser, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kesheng","family":"Wang","sequence":"additional","affiliation":[{"name":"West Virginia University, Morgantown, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafia","family":"Zulfikar","sequence":"additional","affiliation":[{"name":"West Virginia University, Morgantown, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trisha","family":"Petitte","sequence":"additional","affiliation":[{"name":"West Virginia University, Morgantown, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saima","family":"Shafique","sequence":"additional","affiliation":[{"name":"West Virginia University, Morgantown, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol E.","family":"Smith","sequence":"additional","affiliation":[{"name":"University of Kansas Medical Center, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,5,12]]},"reference":[{"key":"bibr1-10547738211015545","volume-title":"Computer-aided multivariate analysis","author":"Afifi A.","year":"2004","edition":"4"},{"key":"bibr2-10547738211015545","unstructured":"American Academy of Sleep Medicine. 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