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A better understanding of the factors associated with COPD-fatigue could elucidate new approaches to address COPD-related fatigue, thereby offering relief to a greater number of patients. The purpose of this review was to identify the physiologic, psychologic, and situational factors associated with COPD-related fatigue. A total of four databases, PubMed, CINAHL, Scopus, and Google Scholar, were searched. Those that were peer reviewed, in English, and published between 2000 and 2021, were included in the review. A total of 25 articles were included in this scoping review. The following factors were related to fatigue in COPD: dyspnea, pain, anxiety, depression, and sleep. Fatigue is a debilitating symptom with factors influential to the symptom and outcomes. Research is indicated to explore targeted and personalized interventions addressing the factors related to fatigue to mitigate this widespread symptom.<\/jats:p>","DOI":"10.1177\/10547738221141224","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T01:35:46Z","timestamp":1671586546000},"page":"914-928","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["COPD-Related Fatigue: A Scoping Review"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7232-662X","authenticated-orcid":false,"given":"Lindsey A.","family":"Clark","sequence":"first","affiliation":[{"name":"University of Maryland School of Nursing, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Reed","sequence":"additional","affiliation":[{"name":"University of Maryland School of Medicine, Baltimore, Maryland, 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