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Patient data were extracted from Clalit Health Services, Israel. A propensity-score analysis was performed matching those exposed to ondansetron with those who were not. Findings identified 774 women exposed to ondansetron, matched 1:1 with unexposed control patients. No significant differences were found between the groups for: cleft palate, cardiovascular congenital abnormalities, spina bifida occulta, preterm delivery, or small for gestational age. Ondansetron may be a useful and safe alternative as treatment for women who suffer from hyperemesis gravidarum and do not respond to other antiemetic drugs. Notwithstanding, additional prospectively designed research is needed to establish the safety of ondansetron treatment during pregnancy.<\/jats:p>","DOI":"10.1177\/10547738231159062","type":"journal-article","created":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T05:26:22Z","timestamp":1678685182000},"page":"705-711","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Ondansetron Use During Pregnancy: Birth Defects and Obstetric Outcomes"],"prefix":"10.1177","volume":"32","author":[{"given":"Sabaa","family":"Masarwe","sequence":"first","affiliation":[{"name":"Department of Nursing, School for Community Health Professions, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Shvartsur","sequence":"additional","affiliation":[{"name":"Department of Nursing, School for Community Health Professions, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel"},{"name":"Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eran","family":"Hadar","sequence":"additional","affiliation":[{"name":"Helen Schneider Hospital for Women, Rabin Medical Center, Petach-Tikva; and Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6672-443X","authenticated-orcid":false,"given":"Batya","family":"Betesh-Abay","sequence":"additional","affiliation":[{"name":"Department of Nursing, School for Community Health Professions, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel"},{"name":"Department of Neonatal Intensive Care, Soroka University Medical Center, Beer-Sheva, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3746-2546","authenticated-orcid":false,"given":"Noam","family":"Peleg","sequence":"additional","affiliation":[{"name":"The Division of Gastroenterology, Rabin Medical Center, Sackler school of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abed N.","family":"Azab","sequence":"additional","affiliation":[{"name":"Department of Nursing, School for Community Health Professions, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel"},{"name":"Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,3,13]]},"reference":[{"issue":"1","key":"bibr1-10547738231159062","volume":"131","author":"American College of Obstetricians and Gynecologists","year":"2018","journal-title":"Obstetrics & Gynecology"},{"key":"bibr2-10547738231159062","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.22865"},{"key":"bibr3-10547738231159062","first-page":"13","volume":"22","author":"Andersen J. 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