{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:43:31Z","timestamp":1777524211232,"version":"3.51.4"},"reference-count":47,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2017,12,18]],"date-time":"2017-12-18T00:00:00Z","timestamp":1513555200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Craniosynostosis (CS) involves the premature fusion of one or more cranial sutures. The etiology of CS is complex and mutations in more than 50 distinct genes have been causally linked to the disorder. Many of the genes that have been associated with CS in humans play an essential role in tissue patterning and early craniofacial development. Among these genes are members of the Hedgehog (HH) and Notch signal transduction pathways, including the GLI family member Gli3, Indian Hedgehog ( Ihh), the RAS oncogene family member Rab23, and the Notch ligand JAGGED1 ( Jag1). We have previously described a colony of rabbits with a heritable pattern of coronal suture synostosis, although the genetic basis for synostosis within this model remains unknown. The present study was performed to determine if coding errors in Gli3, Ihh, Rab23, or Jag1 could be causally linked to craniosynostosis in this unique animal model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Sequencing of cDNA templates was performed using samples obtained from wild-type and craniosynostotic rabbits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Several nucleotide polymorphisms were identified in Gli3, Ihh, and Rab23, although these variants failed to segregate by phenotype. No nucleotide polymorphisms were identified in Jag1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>These data indicate that the causal locus for heritable craniosynostosis in this rabbit model is not located within the protein coding regions of Gli3, Ihh, Rab23, or Jag1.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1055665617739001","type":"journal-article","created":{"date-parts":[[2018,2,13]],"date-time":"2018-02-13T13:03:16Z","timestamp":1518526996000},"page":"375-382","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Molecular Analysis of\n                    <i>Gli3<\/i>\n                    ,\n                    <i>Ihh<\/i>\n                    ,\n                    <i>Rab23<\/i>\n                    , and\n                    <i>Jag1<\/i>\n                    in a Rabbit Model of Craniosynostosis"],"prefix":"10.1177","volume":"55","author":[{"given":"James R.","family":"Gilbert","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery, Children\u2019s Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gwen M.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children\u2019s Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph E.","family":"Losee","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Children\u2019s Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark P.","family":"Mooney","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Children\u2019s Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA"},{"name":"Department of Oral Biology, University of Pittsburgh, Pittsburgh, PA, USA"},{"name":"Department of Anthropology, University of Pittsburgh, Pittsburgh, PA, USA"},{"name":"Department of Orthodontics, University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory M.","family":"Cooper","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Children\u2019s Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA"},{"name":"Department of Oral Biology, University of Pittsburgh, Pittsburgh, PA, USA"},{"name":"Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,12,18]]},"reference":[{"key":"bibr1-1055665617739001","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36811"},{"key":"bibr2-1055665617739001","doi-asserted-by":"publisher","DOI":"10.1017\/S1462399403005751"},{"key":"bibr3-1055665617739001","doi-asserted-by":"publisher","DOI":"10.1002\/ar.a.10113"},{"key":"bibr4-1055665617739001","first-page":"13","volume":"15","author":"Cohen MM","year":"1979","journal-title":"Birth Defects Orig Artic Ser"},{"key":"bibr5-1055665617739001","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320470507"},{"key":"bibr6-1055665617739001","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.30757"},{"key":"bibr7-1055665617739001","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0b013e318193d48d"},{"key":"bibr8-1055665617739001","volume-title":"Craniosynostosis: Diagnosis, Evaluation, and Management","author":"Cohen 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