{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T07:13:51Z","timestamp":1780384431998,"version":"3.54.1"},"reference-count":15,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T00:00:00Z","timestamp":1521763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To examine the birth prevalence of congenital macroglossia and identify demographic variables and comorbidities that may influence length of stay and cost of care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design:<\/jats:title>\n                    <jats:p>Retrospective cross-sectional study using the Kids\u2019 Inpatient Database 2003, 2006, 2009, and 2012.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Demographics were analyzed. Linear regression modeling and multivariate analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The birth prevalence of congenital macroglossia was 4.63\/100 000 births. Patients were classified as isolated (n = 349, 48.1%) or syndromic (n = 377, 51.9%). A higher incidence of isolated macroglossia was seen in females (odds ratio, OR [95% confidence interval, 95% CI]: 1.93 [1.45-2.56] and African Americans (2.02 [1.41-2.88]). Length of stay was higher for syndromic patients than for nonsyndromic patients (22.6 days [18.6-26.6] vs 7.93 days [5.95-9.90], as were inpatient costs ($3619USD [$27 628-$44 754] vs $10 168USD [$6272-$14 064]. After accounting for gender, race, location, and socioeconomic status, the presence of macroglossia alone increased length of stay by 4.07 days (0.42-7.72 days) in nonsyndromic patients and 12.02 days (3.63-20.4 days) in syndromic patients. The cost of care increased by $6207USD ($576-$11 838) among nonsyndromic newborns and $17 205USD ($374-34 035) among syndromic patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The birth prevalence of congenital isolated macroglossia appears to vary by sex and race. Prolonged length of stay and increased costs are associated with both isolated macroglossia and syndromic macroglossia, even after controlling for other syndromic comorbidities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1055665618760898","type":"journal-article","created":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T12:50:25Z","timestamp":1521809425000},"page":"1122-1129","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Neonatal Macroglossia"],"prefix":"10.1177","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2265-1467","authenticated-orcid":false,"given":"Jonathan C.","family":"Simmonds","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\/Head and Neck Surgery, Tufts Medical Center, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anju K.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\/Head and Neck Surgery, Tufts Medical Center, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas R.","family":"Mildenhall","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\/Head and Neck Surgery, Tufts Medical Center, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas S.","family":"Mader","sequence":"additional","affiliation":[{"name":"Chapin Hall at the University of Chicago, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew R.","family":"Scott","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Facial Plastic Surgery, Floating Hospital for Children, Tufts Medical Center, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,3,23]]},"reference":[{"key":"bibr1-1055665618760898","doi-asserted-by":"publisher","DOI":"10.4103\/2231-0746.119230"},{"key":"bibr2-1055665618760898","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0b013e31826cff10"},{"key":"bibr3-1055665618760898","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.30267"},{"key":"bibr4-1055665618760898","doi-asserted-by":"publisher","DOI":"10.1007\/s10024-005-1154-9"},{"key":"bibr15-1055665618760898","unstructured":"HCUP Cost-to-Charge Ratio Files (CCR). Healthcare Cost and Utilization Project (HCUP). 2006-2009. Agency for Healthcare Research and Quality, Rockville, MD. www.hcup-us.ahrq.gov\/db\/state\/costtocharge.jsp. Accessed September 23, 2014."},{"key":"bibr5-1055665618760898","unstructured":"HCUP Kids\u2019 Inpatient Database (KID). Healthcare Cost and Utilization Project (HCUP). 2006 and 2009. Agency for Healthcare Research and Quality, Rockville, MD. www.hcup-us.ahrq.gov\/kidoverview.jsp. Accessed September 23, 2014."},{"key":"bibr6-1055665618760898","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2012.09.003"},{"key":"bibr7-1055665618760898","unstructured":"Hulke JW, Holmes T. A System of Surgery, Theoretical and Practical, in Treatises by Various Authors. Vol 2. London, UK: Longmans, Green, and Company; 1883; 555\u2013559."},{"key":"bibr8-1055665618760898","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2011.10.021"},{"key":"bibr9-1055665618760898","first-page":"444","volume":"65","author":"Myer CM","year":"1986","journal-title":"Ear Nose Throat J"},{"key":"bibr10-1055665618760898","doi-asserted-by":"publisher","DOI":"10.5334\/ijic.91"},{"key":"bibr11-1055665618760898","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-1732"},{"key":"bibr12-1055665618760898","volume-title":"GeneReviews(R)","author":"Shuman C","year":"1993"},{"key":"bibr13-1055665618760898","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-198678060-00001"},{"key":"bibr14-1055665618760898","doi-asserted-by":"publisher","DOI":"10.1597\/04-085r2.1"}],"container-title":["The Cleft Palate Craniofacial Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1055665618760898","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1055665618760898","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1055665618760898","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:19:11Z","timestamp":1777393151000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1055665618760898"}},"subtitle":["Demographics, Cost of Care, and Associated Comorbidities"],"short-title":[],"issued":{"date-parts":[[2018,3,23]]},"references-count":15,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1177\/1055665618760898"],"URL":"https:\/\/doi.org\/10.1177\/1055665618760898","relation":{},"ISSN":["1055-6656","1545-1569"],"issn-type":[{"value":"1055-6656","type":"print"},{"value":"1545-1569","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,23]]}}}