{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:25:31Z","timestamp":1777523131787,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T00:00:00Z","timestamp":1544486400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Assessment of cranial dysmorphism in sagittal synostosis is often subjective but objective measures can be applied. These include cephalic index (CI) and midsagittal vector analysis (MSVA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To assess discriminant validity, construct validity, and responsiveness of CI and MSVA measured from computed tomography (CT) in patients with sagittal synostosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Patients with nonsyndromic isolated sagittal synostosis with complete preoperative (n = 30) and postoperative (n = 13) CT data were included. Age-matched control group (n = 24) comprised of normocephalic patients who underwent CT for reasons related to trauma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcome Measures:<\/jats:title>\n                    <jats:p>Retrospective CT evaluation of CI and MSVA was conducted and correlated with a dysmorphism numeric rating scale (D-NRS) that measured surgeon-rated severity of sagittal synostosis. Responsiveness of CI and MSVA was evaluated using dysmorphism global rating of change (D-GRC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Thirty patients with sagittal synostosis were demographically similar to 24 normocephalic patients. The difference in CI and MSVA was statistically significant between normocephalic and scaphocephalic patients. Cephalic index had a good correlation with D-NRS (\n                      <jats:italic>r<\/jats:italic>\n                      = \u22120.665, \u03c1 = \u22120.667), but not with MSVA (\n                      <jats:italic>r<\/jats:italic>\n                      = 0.250, \u03c1 = 0.203). Change in CI (\n                      <jats:italic>r<\/jats:italic>\n                      = 0.738, \u03c1 = 0.657) was well correlated with D-GRC, but not with MSVA (\n                      <jats:italic>r<\/jats:italic>\n                      = \u22120.409, \u03c1 = \u22120.301).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Cephalic index appears to quantify the severity of sagittal synostosis better than MSVA. Cephalic index also has better responsiveness than MSVA to measure a reduction in severity of disease; however, MSVA is a better descriptive craniometric measurement. Midsagittal vector analysis was able to quantify the shift in morphology in sagittal synostosis following surgical treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1055665618815400","type":"journal-article","created":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T23:11:12Z","timestamp":1544569872000},"page":"944-952","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Comparing Cephalic Index and Midsagittal Vector Analysis in Assessing Morphology in Sagittal Synostosis: A CT-Based Morphometric Analysis"],"prefix":"10.1177","volume":"56","author":[{"given":"Brian Y.","family":"Hong","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily S.","family":"Ho","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Centre for Craniofacial Care and Research, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Zellner","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Centre for Craniofacial Care and Research, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John H.","family":"Phillips","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Centre for Craniofacial Care and Research, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher R.","family":"Forrest","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Centre for Craniofacial Care and Research, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,12,11]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.3171\/2009.8.PEDS09227"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-198508000-00016"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000176897.76579.7c"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199912000-00003"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.scs.0000180008.37739.74"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.32208"},{"issue":"2","key":"e_1_3_3_8_1","first-page":"696","article-title":"Identifying reproducible patterns of calvarial dysmorphology in nonsyndromic sagittal craniosynostosis may affect operative intervention and outcomes assessment","volume":"121","author":"Captier G","year":"2008","unstructured":"Captier G. 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