{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T20:28:05Z","timestamp":1782937685371,"version":"3.54.5"},"reference-count":47,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2019,4,17]],"date-time":"2019-04-17T00:00:00Z","timestamp":1555459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"R56, Oral-facial Clefts: Discovery and Characterization of New Genes","award":["$20,000"],"award-info":[{"award-number":["$20,000"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Orofacial clefts (OFC) are the most common congenital craniofacial anomaly. The relationship between intermarriage (consanguinity) and positive family history for OFC is not well described. Consanguinity rates in developed countries are &lt;1% but are considerably higher in the Middle East (45%). Familial clefting rates in developed countries are under 20% but in the Middle East are reported at 30% or higher.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To determine OFC demographics and to clarify the relationship between consanguinity and familial clefting among Palestinians.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>\n                      The Palestinian Congenial Anomalies Database is based on a 700-question survey administered to mothers of children with congenital anomalies. Orofacial clefts were diagnosed in 540 children. All demographic data were analyzed using \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      tests with a level of significance at \u03b1 &lt; .05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Demographics for OFC among Palestinians were similar to other published reports. Overall consanguinity rate was 53% and familial clefting rate was 49%. Parental rates of consanguinity were significantly different for patients with cleft palate. Patients with consanguineous parents had a higher rate of positive family history of clefting (67%). Recurrence of clefts in siblings was significantly higher among those born to consanguineous parents (73%) when compared to nonconsanguineous parents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Consanguinity rates for Palestinians with OFC were higher than those reported in the Middle East. Familial clefting and sibling recurrence rates were also higher than expected. The risk of OFC may be mitigated with improved education about anticipated genetic consequences of consanguinity in high-risk populations such as the southern West Bank.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1055665619838381","type":"journal-article","created":{"date-parts":[[2019,4,17]],"date-time":"2019-04-17T13:44:12Z","timestamp":1555508652000},"page":"1072-1079","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["The Influence of Consanguinity on Familial Clefting Among Palestinians"],"prefix":"10.1177","volume":"56","author":[{"given":"Omar B.","family":"Saeed","sequence":"first","affiliation":[{"name":"Ohio University Heritage College of Osteopathic Medicine, Athens, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith Grogan","family":"Moore","sequence":"additional","affiliation":[{"name":"University of Cincinnati College of Medicine, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Zawahrah","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Tayem","sequence":"additional","affiliation":[{"name":"Department of Public Health, Faculty of Graduate Studies, An-Najah National University, Nablus, Occupied Palestinian Territories"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tazheh","family":"Kavoosi","sequence":"additional","affiliation":[{"name":"University of Cincinnati College of Medicine, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"van Aalst","sequence":"additional","affiliation":[{"name":"University of Cincinnati College of Medicine, OH, USA"},{"name":"UC Department of Surgery, Cincinnati, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,4,17]]},"reference":[{"key":"bibr2-1055665619838381","doi-asserted-by":"publisher","DOI":"10.1597\/06-246.1"},{"key":"bibr3-1055665619838381","doi-asserted-by":"publisher","DOI":"10.3109\/02844317809010478"},{"key":"bibr4-1055665619838381","doi-asserted-by":"publisher","DOI":"10.3109\/02844317809010477"},{"key":"bibr5-1055665619838381","doi-asserted-by":"publisher","DOI":"10.3109\/02844318109103407"},{"key":"bibr49-1055665619838381","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmhg.2017.01.002"},{"key":"bibr7-1055665619838381","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8933"},{"key":"bibr8-1055665619838381","doi-asserted-by":"publisher","DOI":"10.1597\/12-097"},{"key":"bibr9-1055665619838381","first-page":"5","volume":"2","author":"Canela GGC","year":"2016","journal-title":"Dent Oral Craniofac Res"},{"key":"bibr10-1055665619838381","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569_1999_036_0096_tcdfcp_2.3.co_2"},{"key":"bibr11-1055665619838381","doi-asserted-by":"publisher","DOI":"10.1080\/0301446032000159255"},{"key":"bibr12-1055665619838381","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.32.8.623"},{"key":"bibr13-1055665619838381","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2017-313777"},{"key":"bibr14-1055665619838381","doi-asserted-by":"publisher","DOI":"10.1007\/s12687-011-0072-y"},{"key":"bibr15-1055665619838381","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"bibr16-1055665619838381","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwi214"},{"key":"bibr17-1055665619838381","doi-asserted-by":"publisher","DOI":"10.1017\/S0021932017000372"},{"key":"bibr18-1055665619838381","unstructured":"Jamilian A, Sarkarat F, Jafari M, Neshandar M, Amini E, Khosravi S, Ghassemi A. Family history and risk factors for cleft lip and palate patients and their associated anomalies. 2017;19(3):78\u201383."},{"key":"bibr19-1055665619838381","doi-asserted-by":"publisher","DOI":"10.1016\/S0954-6111(12)70011-2"},{"issue":"78","key":"bibr20-1055665619838381","first-page":"35","volume":"27","author":"Kianifar H","year":"2015","journal-title":"Iran J Otorhinolaryngol"},{"key":"bibr21-1055665619838381","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2002.17.1.49"},{"issue":"5","key":"bibr22-1055665619838381","first-page":"231","volume":"13","author":"Kot M","year":"2007","journal-title":"Med Sci Monit"},{"key":"bibr23-1055665619838381","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4582"},{"key":"bibr25-1055665619838381","doi-asserted-by":"publisher","DOI":"10.1080\/03014468600008541"},{"key":"bibr26-1055665619838381","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60695-4"},{"key":"bibr27-1055665619838381","doi-asserted-by":"publisher","DOI":"10.1054\/bjom.1999.0133"},{"key":"bibr28-1055665619838381","doi-asserted-by":"publisher","DOI":"10.1597\/03-034.1"},{"key":"bibr29-1055665619838381","doi-asserted-by":"publisher","DOI":"10.5195\/jmla.2018.319"},{"key":"bibr30-1055665619838381","doi-asserted-by":"publisher","DOI":"10.1111\/ppe.12497"},{"key":"bibr31-1055665619838381","doi-asserted-by":"publisher","DOI":"10.1007\/s002380100253"},{"key":"bibr32-1055665619838381","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569_2000_037_0191_aesooc_2.3.co_2"},{"key":"bibr33-1055665619838381","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.34432"},{"key":"bibr34-1055665619838381","doi-asserted-by":"publisher","DOI":"10.3109\/02844318209006568"},{"key":"bibr35-1055665619838381","doi-asserted-by":"publisher","DOI":"10.1597\/10-109"},{"key":"bibr36-1055665619838381","doi-asserted-by":"publisher","DOI":"10.1597\/12-209"},{"key":"bibr37-1055665619838381","doi-asserted-by":"publisher","DOI":"10.15537\/smj.2015.9.11823"},{"key":"bibr38-1055665619838381","doi-asserted-by":"publisher","DOI":"10.1111\/cdoe.12395"},{"issue":"12","key":"bibr50-1055665619838381","first-page":"759","volume":"16","author":"Shapira Y","year":"2014","journal-title":"Isr Med Assoc J"},{"key":"bibr39-1055665619838381","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2014.01.003"},{"key":"bibr40-1055665619838381","volume-title":"Characteristics of Oral Cleft Phenotypes: epidemiological and Genetic Studies in Norway","author":"Sivertsen \u00c5","year":"2007"},{"key":"bibr41-1055665619838381","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39458.563611.AE"},{"key":"bibr42-1055665619838381","doi-asserted-by":"publisher","DOI":"10.1597\/09-255"},{"key":"bibr43-1055665619838381","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4755-6-17"},{"key":"bibr44-1055665619838381","doi-asserted-by":"publisher","DOI":"10.1597\/10-019"},{"key":"bibr45-1055665619838381","volume-title":"Global Registry and Database on Craniofacial Anomalies: Report of a WHO Registry Meeting on Craniofacial Anomalies: Baur\u00fa, Brazil, 4-6 December 2001","author":"WHO Registry Meeting on Craniofacial Anomalies","year":"2003"},{"key":"bibr46-1055665619838381","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2016.08.007"},{"key":"bibr47-1055665619838381","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.20229"},{"key":"bibr48-1055665619838381","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19970211)68:4<472::AID-AJMG20>3.0.CO;2-O"}],"container-title":["The Cleft Palate Craniofacial Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1055665619838381","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1055665619838381","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1055665619838381","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:19:54Z","timestamp":1777393194000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1055665619838381"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,17]]},"references-count":47,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1177\/1055665619838381"],"URL":"https:\/\/doi.org\/10.1177\/1055665619838381","relation":{},"ISSN":["1055-6656","1545-1569"],"issn-type":[{"value":"1055-6656","type":"print"},{"value":"1545-1569","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,17]]}}}