{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T05:08:07Z","timestamp":1780722487036,"version":"3.54.1"},"reference-count":34,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T00:00:00Z","timestamp":1568073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100003690","name":"Cleft Palate Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100003690","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The purpose of this study was to analyze the relationship between cranial base, cerebellar, craniofacial, and velopharyngeal (VP) variables in individuals with 22q11.2 deletion syndrome (22q11DS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Thirteen typically developing healthy children and 13 age- and sex-matched individuals with 22q11DS completed a magnetic resonance imaging scan, which was used to examine craniofacial and VP variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A statistically significant difference was noted in cerebellum volumes,\n                      <jats:italic>F<\/jats:italic>\n                      <jats:sub>1,24<\/jats:sub>\n                      = 7.947,\n                      <jats:italic>P = .<\/jats:italic>\n                      010, posterior nasal spine to posterior pharyngeal wall (PNS-PPW),\n                      <jats:italic>F<\/jats:italic>\n                      <jats:sub>1,24<\/jats:sub>\n                      = 4.878,\n                      <jats:italic>P<\/jats:italic>\n                      = .037, nasion-sella-basion (NSB) cranial base angles,\n                      <jats:italic>F<\/jats:italic>\n                      <jats:sub>1,24<\/jats:sub>\n                      = 7.253,\n                      <jats:italic>P = .<\/jats:italic>\n                      013, and sella-basion-opisthion (SBO) cranial base angles,\n                      <jats:italic>F<\/jats:italic>\n                      <jats:sub>1,24<\/jats:sub>\n                      = 9.134,\n                      <jats:italic>P = .<\/jats:italic>\n                      006, between children with 22q11DS and controls. The cerebellum volume was significantly reduced and cranial base angles were significantly more obtuse in individuals with 22q11DS. In the 22q11DS group, cerebellum volume was significantly correlated with sella-basion (SB) length, osseous pharyngeal depth, the PNS-PPW length, and velar length (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .05). The PNS-PPW length was correlated with SB length, basion-opisthion length, NSB angle, SBO angle, and the VP ratio (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study supports previous findings on anatomical differences among individuals with 22q11DS and has expanded our current understanding of the potential relationship between craniofacial and VP variables in at least a subset of children with 22q11DS. Results provide preliminary insights into the potential relationship between a decrease in cerebellar volume, obtuse cranial base angles, and unfavorable VP dimensions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1055665619874175","type":"journal-article","created":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T00:16:15Z","timestamp":1568160975000},"page":"412-419","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Impact of Cranial Base Abnormalities on Cerebellar Volume and the Velopharynx in 22q11.2 Deletion Syndrome"],"prefix":"10.1177","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8821-1037","authenticated-orcid":false,"given":"Abigail E.","family":"Haenssler","sequence":"first","affiliation":[{"name":"Department of Communication Sciences and Disorders, East Carolina University, Greenville, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriane","family":"Baylis","sequence":"additional","affiliation":[{"name":"Nationwide Children\u2019s Hospital, Columbus, OH, USA"},{"name":"The Department of Plastic Surgery, The Ohio State University College of Medicine, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7866-9159","authenticated-orcid":false,"given":"Jamie L.","family":"Perry","sequence":"additional","affiliation":[{"name":"Department of Communication Sciences and Disorders, East Carolina University, Greenville, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshmi","family":"Kollara","sequence":"additional","affiliation":[{"name":"Department of Clinical Health Sciences, Texas A&amp;M University, Kingsville, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangming","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, East Carolina University, Greenville, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Kirschner","sequence":"additional","affiliation":[{"name":"Nationwide Children\u2019s Hospital, Columbus, OH, USA"},{"name":"The Department of Plastic Surgery, The Ohio State University College of Medicine, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,9,10]]},"reference":[{"key":"e_1_3_2_2_1","first-page":"39","article-title":"Craniofacial morphology in the velo-cardio-facial syndrome","volume":"4","author":"Arvystas M","year":"1984","unstructured":"Arvystas M, Shprintzen RJ. 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