{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:26:57Z","timestamp":1777523217048,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T00:00:00Z","timestamp":1572480000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To evaluate pharyngeal pressure profiles during swallowing in patients with unilateral cleft lip and palate (UCLP) and identify compensation mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Prospective experimental study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting:<\/jats:title>\n                    <jats:p>University Hospital and Medical School.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants:<\/jats:title>\n                    <jats:p>Ten volunteers and 10 patients with nonsyndromic repaired UCLP with hypernasality (age: 19-27 years, 5 females and 5 males per group) were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions:<\/jats:title>\n                    <jats:p>All participants swallowed 2 and 10 mL of water and underwent high-resolution manometry (HRM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures:<\/jats:title>\n                    <jats:p>\n                      Pharyngeal and upper esophageal sphincter (UES) parameters were measured using HRM. Student\n                      <jats:italic>t<\/jats:italic>\n                      test was used for statistical intergroup comparisons. Additionally, the Sydney Swallowing Questionnaire (SSQ) was used as a subjective measure.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Patients exhibited reduced velopharyngeal closing pressure and velopharyngeal and tongue base (TB) region contraction times, compared to volunteers (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .05). The UES opening and closing functions did not change. The SSQ revealed nasal regurgitation in some patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>In patients with UCLP, velopharyngeal region alterations are caused by impaired muscle force and function. The reduced TB contraction time may be a compensation mechanism allowing bolus transportation without nasal regurgitation. However, deglutition is not completely altered since UES function remains normal. Future studies will need to reveal at which point a decrease in velopharyngeal closing pressure will result in velopharyngeal insufficiency.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1055665619877053","type":"journal-article","created":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T01:17:23Z","timestamp":1572571043000},"page":"238-244","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Deglutition in Patients With Hypernasality Associated With Unilateral Cleft Lip and Palate Evaluated With High-Resolution Manometry"],"prefix":"10.1177","volume":"57","author":[{"given":"Johanna","family":"Kallusky","sequence":"first","affiliation":[{"name":"Department of Phoniatrics and Pediatric Audiology, Hannover Medical School, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00fcdiger","family":"Zimmerer","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Hannover Medical School, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Tavassol","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Hannover Medical School, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nils-Claudius","family":"Gellrich","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Hannover Medical School, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Ptok","sequence":"additional","affiliation":[{"name":"Department of Phoniatrics and Pediatric Audiology, Hannover Medical School, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4823-3746","authenticated-orcid":false,"given":"Michael","family":"Jungheim","sequence":"additional","affiliation":[{"name":"Department of Phoniatrics and Pediatric Audiology, Hannover Medical School, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,10,31]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ocr.12109"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2006.10.011"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/3-540-30020-1"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-012-2091-7"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000001586"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjorl.2015.10.020"},{"key":"e_1_3_4_8_1","first-page":"181","article-title":"Oral-pharyngeal movements during swallowing and speech","volume":"10","author":"Flowers CR","year":"1973","unstructured":"Flowers CR, Morris HL. 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