{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T20:23:41Z","timestamp":1789503821354,"version":"build-2803163510"},"reference-count":36,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T00:00:00Z","timestamp":1578873600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100006636","name":"Forskningsr\u00e5det om H\u00e4lsa, Arbetsliv och V\u00e4lf\u00e4rd","doi-asserted-by":"crossref","award":["2011-1443"],"award-info":[{"award-number":["2011-1443"]}],"id":[{"id":"10.13039\/501100006636","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To compare speech outcome following different sequencing of hard and soft palate closure between arms and centers within trial 3 and compare results to peers without cleft palate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>A prospective randomized clinical trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting:<\/jats:title>\n                    <jats:p>Two Norwegian and 2 British centers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants:<\/jats:title>\n                    <jats:p>One hundred thirty-six 5-year-olds with unilateral cleft lip and palate were randomized to either lip and soft palate closure at 3 to 4 months and hard palate closure at 12 months (arm A) or lip and hard palate closure at 3 to 4 months and soft palate closure at 12 months (arm D).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures:<\/jats:title>\n                    <jats:p>A composite measure of velopharyngeal competence (VPC), overall assessment of VPC from connected speech (VPC-Rate). Percentage of consonants correct (PCC), active cleft speech characteristics (CSCs), subdivided by oral retracted and nonoral errors, and developmental speech characteristics (DSCs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Across the trial, 47% had VPC, with no statistically significant difference between arms within or across centers. Thirty-eight percent achieved a PCC score of &gt;90%, with no difference between arms or centers. In one center, significantly more children in arm A produced \u22653 active CSCs (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .05). Across centers, there was a statistically significant difference in active CSCs (arm D), oral retracted CSCs (arm D), and DSCs (arms A and D).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Less than half of the 5-year-olds achieved VPC and around one-third achieved age-appropriate PCC scores. Cleft speech characteristics were more common in arm A, but outcomes varied within and across centers. Thus, outcome of the same surgical method can vary substantially across centers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1055665619896637","type":"journal-article","created":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T04:51:55Z","timestamp":1578891115000},"page":"352-363","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Scandcleft Project Trial 3: Comparison of Speech Outcomes in Relation to Sequence in 2-Stage Palatal Repair Procedures in 5-Year-Olds With Unilateral Cleft Lip and Palate"],"prefix":"10.1177","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7860-1573","authenticated-orcid":false,"given":"Christina","family":"Persson","sequence":"first","affiliation":[{"name":"Institute of Neuroscience and Physiology, Speech and Language Pathology Unit, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden"},{"name":"Department of Speech and Language Pathology\/ENT, Sahlgrenska University Hospital, Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina-Helen","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Statped Vest, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Hayden","sequence":"additional","affiliation":[{"name":"The Royal Hospital for Sick Children, Belfast, Northern Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Bowden","sequence":"additional","affiliation":[{"name":"Greater Manchester Cleft Unit, Royal Manchester Children\u2019s Hospital, Manchester, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ragnhild","family":"Aukner","sequence":"additional","affiliation":[{"name":"Department of Speech and Language Disorders, Statped s\u00f8r\u00f8st, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hallvard A.","family":"Vindenes","sequence":"additional","affiliation":[{"name":"Center for Cleft Lip and Palate, Bergen University Hospital Haukeland, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"\u00c5byholm","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Oslo University Hospital, Rikshospitalet, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Withby","sequence":"additional","affiliation":[{"name":"Greater Manchester Cleft Unit, Royal Manchester Children\u2019s Hospital, Manchester, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9013-8764","authenticated-orcid":false,"given":"Elisabeth","family":"Willadsen","sequence":"additional","affiliation":[{"name":"Department of Nordic Studies and Linguistics, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anette","family":"Lohmander","sequence":"additional","affiliation":[{"name":"Division of Speech and Language Pathology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,1,13]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1597\/13-121"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/0269920031000111348"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2015.03.033"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1597\/10-033"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118785065.ch9"},{"issue":"2","key":"e_1_3_4_7_1","first-page":"126","article-title":"Strategies in cleft palate speech\u2014with special reference to Danish","volume":"24","author":"Hutters B","year":"1987","unstructured":"Hutters B, Br\u00f8ndsted K. 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