{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T03:10:47Z","timestamp":1782443447176,"version":"3.54.5"},"reference-count":24,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T00:00:00Z","timestamp":1600041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81602795;21606062"],"award-info":[{"award-number":["81602795;21606062"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To determine the risk factors of the occurrence of nonsyndromic cleft lip and\/or cleft palate (NSCL\/P) in Xinjiang Province, China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>\n                      The study included 359 patients of NSCL\/P and 310 controls. Information about sociodemographic characteristics, lifestyle behaviors, negative life events, possible environmental hazards exposures, and use of supplementations were collected from cases and controls. Both\n                      <jats:italic>t<\/jats:italic>\n                      test and \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      tests were used for group comparisons. Multivariable logistic regression was used to estimate the independent associations between environmental risk factors and the presence of NSCL\/P. The receiver operating characteristic curve was used to establish the predictive variables for the occurrence of NSCL\/P.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The results showed that maternal pesticide exposure (odds ratio [OR] = 11.40, 95%CI: 5.40-24.10), antibiotic drugs use (OR = 1.32, 95%CI: 1.14-1.53), paternal smoking (OR = 3.30, 95%CI: 1.87-5.83), threatened abortion (OR = 12.2, 95%CI: 3.29-45.25) were associated with increased risk of NSCL\/P in offspring. In contrast, maternal moderate (OR = 0.43, 95%CI: 0.20-0.92) and middle physical workload (OR = 0.48, 95%CI: 0.0.23-0.97), vitamin-B complex supplementations (OR = 0.11, 95%CI: 0.03-0.41), calcium and iron (OR = 0.27, 95%CI: 0.08-0.90) supplementations were associated with reduced risk of NSCL\/P in offspring. These variables together explain nearly 60% of the variation of occurrence of NSCL\/P.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>These findings from our study may help to develop primary prevention strategies for NSCL\/P in Xinjiang.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1055665620956869","type":"journal-article","created":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T05:45:08Z","timestamp":1600062308000},"page":"489-496","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Environmental Risk Factors for Nonsyndromic Cleft Lip and\/or Cleft Palate in Xinjiang Province, China: A Multiethnic Study"],"prefix":"10.1177","volume":"58","author":[{"given":"Yu","family":"Hong","sequence":"first","affiliation":[{"name":"Department of Preventive Medicine, School of Medicine, Hangzhou Normal University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2406-3690","authenticated-orcid":false,"given":"Xianrong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, School of Medicine, Hangzhou Normal University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuzhi","family":"Lian","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, School of Medicine, Hangzhou Normal University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, School of Medicine, Hangzhou Normal University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,9,14]]},"reference":[{"issue":"3","key":"e_1_3_2_2_1","first-page":"279","article-title":"Prevalence and evaluation of environmental risk factors associated with cleft lip and palate in a central Indian population","volume":"35","author":"Acta Odontol ScandKalaskar R","year":"2013","unstructured":"Acta Odontol ScandKalaskar R, Kalaskar A, Naqvi FS, Tawani GS, Walke DR. 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