{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T05:22:33Z","timestamp":1783401753717,"version":"3.54.6"},"reference-count":31,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T00:00:00Z","timestamp":1600214400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior \u2013 Brasil","doi-asserted-by":"crossref","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      The aim of this study was to use dental development as a tool to subphenotype oral clefts and investigate the association of\n                      <jats:italic toggle=\"yes\">MMP2<\/jats:italic>\n                      with dentin-pulp complex anomalies, in order to identify dental anomalies that are a part of a \u201ccleft syndrome.\u201d\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>\n                      Two hundred and ninety individuals born with cleft lip and palate were evaluated and several clinical features, such as cleft completeness or incompleteness, laterality, and presence of dental anomalies were used to assess each individual\u2019s cleft status. We tested for overrepresentation of\n                      <jats:italic toggle=\"yes\">MMP2<\/jats:italic>\n                      single nucleotide polymorphism rs9923304 alleles depending on individuals having certain dental anomalies. Chi-square and Fisher exact tests were used in all comparisons (\u03b1 = .05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      All individuals studied had at least one dental anomaly outside the cleft area. Significant differences between individuals born with clefts with and without talon cusp (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .04) were observed for the frequency of the\n                      <jats:italic toggle=\"yes\">MMP2<\/jats:italic>\n                      less common allele.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      All individuals born with cleft lip and palate had alterations of the dentition, and a quarter to half of the individuals had alterations of the internal anatomy of their teeth, which further indicates that dental anomalies can be considered as an extended phenotype for clefts.\n                      <jats:italic toggle=\"yes\">MMP2<\/jats:italic>\n                      was associated with talon cusp in individuals born with oral clefts.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1055665620958569","type":"journal-article","created":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T06:30:28Z","timestamp":1600237828000},"page":"597-602","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Talon Cusp Associates With MMP2 in a Cohort of Individuals Born With Oral Clefts"],"prefix":"10.1177","volume":"58","author":[{"given":"Bianca G. N.","family":"Cavalcante","sequence":"first","affiliation":[{"name":"Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa Helena W.","family":"Lacerda","sequence":"additional","affiliation":[{"name":"Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ion\u00e1ria O.","family":"Assis","sequence":"additional","affiliation":[{"name":"Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Bezamat","sequence":"additional","affiliation":[{"name":"University of Pittsburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4414-069X","authenticated-orcid":false,"given":"Adriana","family":"Modesto","sequence":"additional","affiliation":[{"name":"University of Pittsburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3392-6881","authenticated-orcid":false,"given":"Alexandre R.","family":"Vieira","sequence":"additional","affiliation":[{"name":"University of Pittsburgh"},{"name":"Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,9,16]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.580"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12746-w"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.30252"},{"key":"e_1_3_4_5_1","volume-title":"Inheritance of Harelip and Cleft Palate","author":"Fogh-Andersen P","year":"1942","unstructured":"Fogh-Andersen P. Inheritance of Harelip and Cleft Palate. Arnold Busck; 1942."},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.5732\/cjc.012.10151"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2018.01.007"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-05764-5"},{"issue":"1","key":"e_1_3_4_9_1","first-page":"10","article-title":"From caries progression and restoration failures to periapical lesions in the era of precision","volume":"5","author":"Leonardi DP","year":"2020","unstructured":"Leonardi DP, Vieira AR. From caries progression and restoration failures to periapical lesions in the era of precision. JDR Clin Trans Res. 2020;5(1):10\u201312.","journal-title":"JDR Clin Trans Res"},{"issue":"7","key":"e_1_3_4_10_1","first-page":"989","article-title":"Defining sub phenotypes for oral clefts based on dental development","volume":"86","author":"Letra A","year":"2007","unstructured":"Letra A, Menezes R, Granjeiro JM, Vieira AR. Defining sub phenotypes for oral clefts based on dental development. J Dent Res. 2007;86(7):989\u2013991.","journal-title":"J Dent Res"},{"key":"e_1_3_4_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23026"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2012007500150"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33136"},{"key":"e_1_3_4_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2350-11-40"},{"key":"e_1_3_4_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000224636"},{"key":"e_1_3_4_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/90100"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.1597\/07-064.1"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2012.02.009"},{"key":"e_1_3_4_19_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1698866"},{"key":"e_1_3_4_20_1","doi-asserted-by":"publisher","DOI":"10.1597\/10-067"},{"key":"e_1_3_4_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004390000239"},{"key":"e_1_3_4_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/19.1.149"},{"key":"e_1_3_4_23_1","doi-asserted-by":"publisher","DOI":"10.1086\/519795"},{"key":"e_1_3_4_24_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.157801"},{"key":"e_1_3_4_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31673"},{"key":"e_1_3_4_26_1","volume-title":"Incid\u00eancia e Caracteriza\u00e7\u00e3o De Fendas Orofaciais em Nascidos Vivos registrados em Dados do SINAC (DATASUS) \u2013 Para\u00edba \u2013 de 2002 a 2010 [Trabalho de Conclus\u00e3o de Curso]","author":"Sousa ALB","year":"2014","unstructured":"Sousa ALB. Incid\u00eancia e Caracteriza\u00e7\u00e3o De Fendas Orofaciais em Nascidos Vivos registrados em Dados do SINAC (DATASUS) \u2013 Para\u00edba \u2013 de 2002 a 2010 [Trabalho de Conclus\u00e3o de Curso]. Universidade Estadual da Para\u00edba; 2014."},{"key":"e_1_3_4_27_1","doi-asserted-by":"publisher","DOI":"10.1159\/000337521"},{"issue":"1","key":"e_1_3_4_28_1","first-page":"93","article-title":"Three decades of molecular studies of multifactorial cleft lip and palate","volume":"2","author":"Vieira AR","year":"2017","unstructured":"Vieira AR. Three decades of molecular studies of multifactorial cleft lip and palate. JDR Clin Trans Res. 2017;2(1):93\u201394.","journal-title":"JDR Clin Trans Res"},{"key":"e_1_3_4_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.32295"},{"key":"e_1_3_4_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e3181833793"},{"key":"e_1_3_4_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2017.00186"},{"key":"e_1_3_4_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.20283"}],"container-title":["The Cleft Palate Craniofacial Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1055665620958569","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1055665620958569","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1055665620958569","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:21:02Z","timestamp":1777393262000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1055665620958569"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,16]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1177\/1055665620958569"],"URL":"https:\/\/doi.org\/10.1177\/1055665620958569","relation":{},"ISSN":["1055-6656","1545-1569"],"issn-type":[{"value":"1055-6656","type":"print"},{"value":"1545-1569","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,16]]}}}