{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T19:20:58Z","timestamp":1793215258956,"version":"4.5.0"},"reference-count":56,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T00:00:00Z","timestamp":1602633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To evaluate bone regeneration in alveolar defects treated with human umbilical cord\u2013derived mesenchymal stem cells (hUCMSCs), hydroxyapatite\/chitosan\/gelatin (HA\/CS\/Gel) scaffold, and bone morphogenic protein-2 (BMP-2) in Capra hircus models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Randomized posttest-only control group design.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting:<\/jats:title>\n                    <jats:p>Animal Hospital at Bogor Agricultural Institute.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants:<\/jats:title>\n                    <jats:p>Healthy and equally treated 24 female Capra hircus\/goats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Intervention:<\/jats:title>\n                    <jats:p>Animals were randomly assigned to 3 experimental group design (iliac crest alveolar bone graft\/ICABG [control], HA\/Cs\/Gel+BMP-2 [ Novosys], and HA\/Cs\/Gel+BMP-2+UCMSCs). Graft materials were implanted in surgically made alveolar defects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures:<\/jats:title>\n                    <jats:p>Postoperative functional score and operating time were assessed. New bone growth, bone density, inflammatory cells recruitment, and neoangiogenesis were evaluated based on radiological and histological approach at 2 time points, week 4 and 12. Statistical analysis was done between treatment groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Operating time was 34% faster and functional score 94.5% more superior in HA\/Cs\/Gel+BMP-2+hUCMSC group. Bone growth capacity in HA\/Cs\/Gel+BMP-2+UCMSCs mimicked ICABG, but ICABG showed possibility of bone loss between week 4 and 12. The HA\/Cs\/Gel+BMP-2+UCMSCs showed early bone repopulation and unseen inflammatory cells and angiogenesis on week 12.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion and Conclusion:<\/jats:title>\n                    <jats:p>The HA\/Cs\/Gel+BMP-2+hUCMSCs were superior in enhancing new bone growth without donor site morbidity compared to ICABG. The presence of hUCMSCs in tissue-engineered alveolar bone graft (ABG), supported with paracrine activity of the resident stem cells, initiated earlier new bone repopulation, and completed faster bone regeneration. The HA\/Cs\/Gel scaffold seeded with UCMSCs+BMP-2 is a safe substitute of ICABG to close alveolar bone defects suitable for patients with cleft lip, alveolus, and palate.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1055665620962360","type":"journal-article","created":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T06:39:41Z","timestamp":1602657581000},"page":"707-717","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Bone Growth Capacity of Human Umbilical Cord Mesenchymal Stem Cells and BMP-2 Seeded Into Hydroxyapatite\/Chitosan\/Gelatin Scaffold in Alveolar Cleft Defects: An Experimental Study in Goat"],"prefix":"10.1177","volume":"58","author":[{"given":"Kristaninta","family":"Bangun","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Cleft and Craniofacial Center, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaula L.","family":"Sukasah","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Cleft and Craniofacial Center, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia"},{"name":"Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismail H.","family":"Dilogo","sequence":"additional","affiliation":[{"name":"Unit Pelayanan Terpadu Teknologi Kedokteran Sel Punca (Stem Cell Research Center), Cipto Mangunkusumo General Hospital, Jakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Decky J.","family":"Indrani","sequence":"additional","affiliation":[{"name":"Department of Dental Material Science and Technology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurjati Chairani","family":"Siregar","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia"},{"name":"Anatomical Pathology Department, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacub","family":"Pandelaki","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia"},{"name":"Radiology Department of Cipto Mangunkusumo General Hospital, Jakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diah","family":"Iskandriati","sequence":"additional","affiliation":[{"name":"Primate Research Center of Bogor Agricultural Institute, Bogor, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aria","family":"Kekalih","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia"},{"name":"Community Medicine Department, Cipto 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