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All patients requiring clinical genetics assessment in Operation Smile Foundation were included in the study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Left cleft lip and palate (CLP) and nonsyndromic forms were the most frequent types of malformations in this population. Psychomotor retardation and heart disease were the most frequent comorbidities in these patients. A low proportion of mothers exposed to passive smoking during pregnancy was observed and low birth weight accounted for an important number of cases. Aarskog, velocardiofacial, and orofaciodigital syndromes were the most frequent syndromic forms of CLP in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>In this study, the most frequent type of CL\/P was the nonsyndromic complete left CLP. Aarskog, velocardiofacial, and orofaciodigital syndromes were the most frequent syndromic forms of CL\/P in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10556656211000551","type":"journal-article","created":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T04:55:08Z","timestamp":1616129708000},"page":"200-208","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Clinical and Descriptive Study of Orofacial Clefts in Colombia: 2069 Patients From Operation Smile Foundation"],"prefix":"10.1177","volume":"59","author":[{"given":"Alejandro Silva","family":"Espinosa","sequence":"first","affiliation":[{"name":"Universidad de La Sabana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0704-472X","authenticated-orcid":false,"given":"Julio Cesar","family":"Martinez","sequence":"additional","affiliation":[{"name":"Universidad de La Sabana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yubahhaline","family":"Molina","sequence":"additional","affiliation":[{"name":"Universidad de La Sabana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Alejandra Berm\u00fadez","family":"Gordillo","sequence":"additional","affiliation":[{"name":"Universidad de La Sabana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel Ramos","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Universidad de La Sabana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela Z\u00e1rate","family":"Rivera","sequence":"additional","affiliation":[{"name":"Universidad de La Sabana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8314-5958","authenticated-orcid":false,"given":"Blanka Pacheco","family":"Olmos","sequence":"additional","affiliation":[{"name":"Universidad de La Sabana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathaly","family":"Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Universidad de La Sabana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliana","family":"Arias","sequence":"additional","affiliation":[{"name":"Universidad de La Sabana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andres","family":"Zarate","sequence":"additional","affiliation":[{"name":"Universidad de La Sabana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6488-9334","authenticated-orcid":false,"given":"Q.","family":"Diana Marcela Diaz","sequence":"additional","affiliation":[{"name":"Universidad de La Sabana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Collins","sequence":"additional","affiliation":[{"name":"Genetic Epidemiology &amp; Genomic Informatics, Southampton University, Southampton, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1lvaro Mauricio Herrera","family":"Cepeda","sequence":"additional","affiliation":[{"name":"Operation Smile Foundation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio Brice\u00f1o","family":"Balcazar","sequence":"additional","affiliation":[{"name":"Universidad de La Sabana"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,3,19]]},"reference":[{"issue":"348465","key":"e_1_3_3_2_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5402\/2013\/348465","article-title":"Orofacial clefts: a worldwide review of the problem","volume":"2013","author":"Agbenorku P","year":"2013","unstructured":"Agbenorku P. 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