{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:33:19Z","timestamp":1777523599110,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","award":["Research for Patient Benefit (RfPB) Programme (Gra"],"award-info":[{"award-number":["Research for Patient Benefit (RfPB) Programme (Gra"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Cleft palate (CP) can affect breathing, leading to sleep-disordered breathing (SDB). Sleep position can affect SDB, but the optimum sleep position for infants with CP is unknown. We aimed to determine the design of a pragmatic study to investigate the effect of the 2 routinely advised sleep positions in infants with CP on oxygen saturations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>A multicentered observational cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting:<\/jats:title>\n                    <jats:p>Four UK-based cleft centers, 2 advising supine- and 2 side-lying sleep positions for infants with CP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants:<\/jats:title>\n                    <jats:p>Infants with isolated CP born July 1, 2015, and December 31, 2016. Of 48 eligible infants, 30 consented (17 side-lying; 13 supine).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions:<\/jats:title>\n                    <jats:p>\n                      Oxygen saturation (SpO\n                      <jats:sub>2<\/jats:sub>\n                      ) and end-tidal carbon dioxide (ETCO\n                      <jats:sub>2<\/jats:sub>\n                      ) home monitoring at age 1 and 3 months. Qualitative interviews of parents.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcome Measures:<\/jats:title>\n                    <jats:p>\n                      Willingness to participate, recruitment, retention, and acceptability\/success (&gt;90 minutes recording) of SpO\n                      <jats:sub>2<\/jats:sub>\n                      and ETCO\n                      <jats:sub>2<\/jats:sub>\n                      monitoring.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      SpO\n                      <jats:sub>2<\/jats:sub>\n                      recordings were obtained during 50 sleep sessions on 24 babies (13 side-lying) at 1 month (34 sessions &gt;90 minutes) and 50 sessions on 19 babies (10 side-lying) at 3 months (27 sessions &gt;90 minutes). The ETCO\n                      <jats:sub>2<\/jats:sub>\n                      monitoring was only achieved in 12 sessions at 1 month and 6 at 3 months; only 1 was &gt;90 minutes long. The ETCO\n                      <jats:sub>2<\/jats:sub>\n                      monitoring was reported by the majority as unacceptable. Parents consistently reported the topic of sleep position in CP to be of importance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This study has demonstrated that it is feasible to perform domiciliary oxygen saturation studies in a research setting and has suggested that there may be a difference in the effects of sleep position that requires further investigation. We propose a study with randomization is indicated, comparing side-lying with supine-lying sleep position, representing an important step toward better understanding of SDB in infants with CP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10556656211003459","type":"journal-article","created":{"date-parts":[[2021,4,2]],"date-time":"2021-04-02T02:29:14Z","timestamp":1617330554000},"page":"254-261","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Does Sleep Position Influence Sleep-Disordered Breathing in Infants With Cleft Palate: A Feasibility Study?"],"prefix":"10.1177","volume":"59","author":[{"given":"Clare S.","family":"Murray","sequence":"first","affiliation":[{"name":"Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, University of Manchester, Manchester, UK"},{"name":"Royal Manchester Children\u2019s Hospital, Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanya","family":"Walsh","sequence":"additional","affiliation":[{"name":"Division of Dentistry, School of Medical Sciences, University of Manchester, Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trisha","family":"Bannister","sequence":"additional","affiliation":[{"name":"Cleft and Craniofacial Clinical Research Centre, Division of Dentistry, University of Manchester, Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9871-5167","authenticated-orcid":false,"given":"Aleksandra","family":"Metryka","sequence":"additional","affiliation":[{"name":"Royal Manchester Children\u2019s Hospital, Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Davies","sequence":"additional","affiliation":[{"name":"Cleft and Craniofacial Clinical Research Centre, Division of Dentistry, University of Manchester, Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4592-5392","authenticated-orcid":false,"given":"Yin Ling","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Dentistry, School of Medical Sciences, University of Manchester, Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Williamson","sequence":"additional","affiliation":[{"name":"Clinical Trials Research Centre, Institute of Translational Medicine, University of Liverpool, Liverpool, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Callery","sequence":"additional","affiliation":[{"name":"Division of Nursing, Midwifery and Social Work, University of Manchester, Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"O\u2019Brien","sequence":"additional","affiliation":[{"name":"Manchester Clinical Trials Unit, School of Health Sciences, University of Manchester, Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Shaw","sequence":"additional","affiliation":[{"name":"Cleft and Craniofacial Clinical Research Centre, Division of Dentistry, University of Manchester, Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iain","family":"Bruce","sequence":"additional","affiliation":[{"name":"Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, University of Manchester, Manchester, UK"},{"name":"Royal Manchester Children\u2019s Hospital, Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"On behalf of the SLUMBRS Study Advisory Group (SAG) and Respiratory Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,4]]},"reference":[{"issue":"8","key":"e_1_3_3_2_1","first-page":"1848375","article-title":"Review of and updates on hypertension in obstructive sleep apnea","volume":"2017","author":"Ahmad M","year":"2017","unstructured":"Ahmad M, Makati D, Akbar S. 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