{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T19:29:15Z","timestamp":1778354955535,"version":"3.51.4"},"reference-count":48,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T00:00:00Z","timestamp":1617840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"The Smile Train"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The objective of this systematic review was to evaluate the evidence regarding skeletal maturation in patients with cleft lip and\/or palate (CL\/P) and to investigate whether the skeletal maturation is delayed in these patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Systematic review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Electronic and manual searches of scientific literature were conducted in 4 databases (MEDLINE, Embase, Cochrane Library, and Web of Science). Cohort studies that compared the skeletal maturation of patients with CL\/P with that of children without CL\/P were eligible for inclusion. The quality of included cohort studies was assessed using the Newcastle-Ottawa Scale.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Participants:<\/jats:title>\n                    <jats:p>Patients of any sex and ethnicity with CL\/P and children without CL\/P were included in this systematic review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures:<\/jats:title>\n                    <jats:p>Difference in skeletal maturation between patients with CL\/P and patients without CL\/P.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Thirteen retrospective cohort studies were included in this systematic review. Ten studies were considered of high quality and 3 were considered of general quality. The results of the included studies comparing skeletal maturation of patients with CL\/P and children without CL\/P were heterogeneous.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Heterogeneity of skeletal maturation assessment methods, chronological age, sex, cleft type, and race may influence the final results of clinical studies on skeletal maturation in patients with CL\/P. Overall, there is limited evidence to determine whether the skeletal maturation level of patients with CL\/P is delayed compared to that of normal children. Further studies are needed to determine the skeletal maturation patterns in patients with CL\/P.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10556656211007680","type":"journal-article","created":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T04:25:16Z","timestamp":1617855916000},"page":"307-319","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Skeletal Maturation in Patients With Cleft Lip and\/or Palate: A Systematic Review"],"prefix":"10.1177","volume":"59","author":[{"given":"Xiaoyi","family":"Wu","sequence":"first","affiliation":[{"name":"School of Stomatology, Wuhan University, Hubei, People\u2019s Republic of China"},{"name":"State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Hubei, People\u2019s Republic of 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