{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T22:20:52Z","timestamp":1792448452835,"version":"4.5.0"},"reference-count":51,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T00:00:00Z","timestamp":1619049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The aim of this systematic review and meta-analysis was to investigate long-term treatment effects of nasoalveolar molding (NAM) in patients with unilateral cleft lip and palate (UCLP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Included manuscripts met the following criteria: (1) involved patients with UCLP who received NAM; (2) included comparison group(s) who either received non-NAM passive presurgical infant orthopedic appliances (PSIO) or who did not receive any PSIO; (3) reported at least one objective or validated measure of nasolabial, craniofacial, or palatal form; and (4) had patient follow-up beyond 4 years of age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 12 studies were included in this review. Meta-analyses were possible for Asher-McDade parameters and cephalometric measurements. Compared to patients who did not receive any PSIO, those who underwent NAM therapy were more likely to have good to excellent frontal nasal form (Risk ratio: 2.4, 95% CI: 1.24-3.68) and vermillion border (Risk ratio: 1.8, 95% CI: 1.19-2.71). However, there were no statistically significant differences in cephalometric measurements between these groups. Additionally, there were no statistically significant differences between patients receiving NAM versus non-NAM PSIO. There was insufficient evidence to determine the impact of NAM on dental arch development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The preponderance of evidence in this review suggests that NAM produces benefits in nasolabial aesthetic form when compared with no appliance-based presurgical treatment. However, there is insufficient evidence to conclude whether NAM produces such benefits when compared with other passive PSIOs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10556656211009702","type":"journal-article","created":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T03:54:37Z","timestamp":1619063677000},"page":"462-474","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":42,"title":["Long-Term Effects of Nasoalveolar Molding in Patients With Unilateral Cleft Lip and Palate: A Systematic Review and Meta-Analysis"],"prefix":"10.1177","volume":"59","author":[{"given":"William M.","family":"Padovano","sequence":"first","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Washington University in St. Louis School of Medicine, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1138-5201","authenticated-orcid":false,"given":"Gary B.","family":"Skolnick","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Washington University in St. Louis School of Medicine, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sybill D.","family":"Naidoo","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Washington University in St. Louis School of Medicine, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison K.","family":"Snyder-Warwick","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Washington University in St. Louis School of Medicine, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7441-2102","authenticated-orcid":false,"given":"Kamlesh B.","family":"Patel","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Washington University in St. Louis School of Medicine, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,4,22]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e31825dc10a"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2017.08.012"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000001764"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2753.2010.01516.x"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569_1991_028_0385_doamfr_2.3.co_2"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e318199f46e"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1055665618764952"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1597\/02-119.2.1"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3181ec21e4"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0b013e318200d874"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000007492"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:PREV.0000013981.28071.52"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000004959"},{"issue":"7","key":"e_1_3_2_15_1","first-page":"1422","article-title":"Preoperative columella lengthening in bilateral cleft lip and palate","volume":"92","author":"Grayson BH","year":"1993","unstructured":"Grayson BH, Cutting C, Wood R. 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