{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T03:03:09Z","timestamp":1781578989626,"version":"3.54.5"},"reference-count":29,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T00:00:00Z","timestamp":1619568000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This study examines phenotypic presentation and perioperative outcomes of cleft-related procedures for infants with cleft lip and\/or palate (CL\/P) and prenatal opioid exposure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>This is a retrospective review of infants with prenatal opioid exposure treated for CL\/P from 2008 to 2018.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting:<\/jats:title>\n                    <jats:p>Patients cared for at a tertiary center from 2008 to 2018.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients\/Participants:<\/jats:title>\n                    <jats:p>Eighteen patients with documented prenatal opioid exposure and CL\/P had primary repairs in our unit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measure(s):<\/jats:title>\n                    <jats:p>The phenotypes of CL\/P were characterized. Demographic data regarding additional exposures, as well as associated medical and social comorbidities were recorded. Outcome variables included operative delays, perioperative complications, and loss of follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Isolated cleft palate (CP; 67%) was overrepresented among patients with prenatal opioid exposure and CL\/P, as was Robin sequence (50% in isolated CP). Fifty-six percent had exposure to additional substances. A majority (67%) had other medical conditions or anomalies, and 17% had known genetic syndromes. Seventy-two percent were in state custody. Thirty-nine percent of exposed patients had delays in their planned operative dates due to medical and\/or social factors. There were no postoperative readmissions following cleft procedures. Lack of follow-up was noted in 33% of patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Infants with CL\/P who have prenatal opioid exposure are likely to have additional medical conditions and complex social challenges.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10556656211011896","type":"journal-article","created":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T03:45:09Z","timestamp":1619581509000},"page":"497-504","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Cleft Lip and Palate in Infants With Prenatal Opioid Exposure"],"prefix":"10.1177","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3427-0370","authenticated-orcid":false,"given":"Olivia","family":"Langa","sequence":"first","affiliation":[{"name":"Department of Plastic and Oral Surgery, Boston Children\u2019s Hospital and Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex T.","family":"Cappitelli","sequence":"additional","affiliation":[{"name":"Department of Plastic and Oral Surgery, Boston Children\u2019s Hospital and Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6751-6990","authenticated-orcid":false,"given":"Ingrid M.","family":"Ganske","sequence":"additional","affiliation":[{"name":"Department of Plastic and Oral Surgery, Boston Children\u2019s Hospital and Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,4,28]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1055665620924915"},{"issue":"3","key":"e_1_3_2_3_1","first-page":"336","article-title":"Exposure to prescribed drugs in pregnancy and association with congenital malformations","volume":"58","author":"Bracken MB","year":"1981","unstructured":"Bracken MB, Holford TR. 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