{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T11:43:46Z","timestamp":1791632626197,"version":"4.3.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T00:00:00Z","timestamp":1626220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      To examine oral colonization and virulence factors of\n                      <jats:italic>Candida<\/jats:italic>\n                      spp. in patients aged from 0 to 18 months with cleft palate (CP).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      Sixty babies were allocated into 3 groups: CP, CP with orthodontic plate (CPwP), and control group (Ctrl) without CP. Information on feeding habits, hygiene, and history of candidosis was collected. The presence of\n                      <jats:italic>Candida<\/jats:italic>\n                      spp. was investigated in samples of saliva. Fungal hydrophobicity, protease, esterase, phospholipase, and hemolysin were evaluated in a semiquantitative manner.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Positive oral isolations of\n                      <jats:italic>Candida<\/jats:italic>\n                      spp. were detected in CP (89.5%), CPwP (100%), and Ctrl (44%) groups. Candidosis was more reported in the cleft groups than in the Ctrl group (\n                      <jats:italic>P<\/jats:italic>\n                      \u2264 .023). There was a higher prevalence of\n                      <jats:italic>Candida albicans<\/jats:italic>\n                      , followed by\n                      <jats:italic>Candida krusei<\/jats:italic>\n                      ,\n                      <jats:italic>Candida tropicalis<\/jats:italic>\n                      , and\n                      <jats:italic>Candida parapsilosis<\/jats:italic>\n                      in all groups. There was no uniformity of expression of virulence factors, either among different species or among different groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Candida<\/jats:italic>\n                      spp. colonization occurred in all groups, being superior in CPwP group. Candidosis episodes were more reported in patients from CPwP than in other groups, although candidosis was also registered in other groups.\n                      <jats:italic>Candida albicans<\/jats:italic>\n                      was the predominant species and virulence factors did not exhibit any pattern for species or groups of patients.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10556656211030437","type":"journal-article","created":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T05:09:55Z","timestamp":1626239395000},"page":"1056-1063","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Oral Colonization and Virulence Factors of\n                    <i>Candida<\/i>\n                    spp. in Babies With Cleft Palate"],"prefix":"10.1177","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6134-0007","authenticated-orcid":false,"given":"Patr\u00edcia Tolentino da Rosa","family":"de Souza","sequence":"first","affiliation":[{"name":"Pontifical Catholic University from Paran\u00e1, School of Life Sciences, Curitiba, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilza Cristina Valor","family":"Gon\u00e7alves-Wilhelmsen","sequence":"additional","affiliation":[{"name":"Center for Research and Rehabilitation of Lip and Palate Lesion, Centrinho Prefeito Luiz Gomes, Joinville, Santa Catarina, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosimeire Takaki","family":"Rosa","sequence":"additional","affiliation":[{"name":"Pontifical Catholic University from Paran\u00e1, School of Life Sciences, Curitiba, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarice de Fatima Kamaroski Noan","family":"Correia","sequence":"additional","affiliation":[{"name":"Pontifical Catholic University from Paran\u00e1, School of Life Sciences, Curitiba, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thais Munhoz","family":"Pereira","sequence":"additional","affiliation":[{"name":"Pontifical Catholic University from Paran\u00e1, School of Life Sciences, Curitiba, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldini Beuting Pereira","family":"Kitahara","sequence":"additional","affiliation":[{"name":"Pontifical Catholic University from Paran\u00e1, School of Life Sciences, Curitiba, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9rgio Aparecido","family":"Ign\u00e1cio","sequence":"additional","affiliation":[{"name":"Pontifical Catholic University from Paran\u00e1, School of Life Sciences, Curitiba, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana Reis","family":"Azevedo-Alanis","sequence":"additional","affiliation":[{"name":"Pontifical Catholic University from Paran\u00e1, School of Life Sciences, Curitiba, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edvaldo Ant\u00f4nio Ribeiro","family":"Rosa","sequence":"additional","affiliation":[{"name":"Pontifical Catholic University from Paran\u00e1, School of Life Sciences, Curitiba, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,7,14]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032513"},{"issue":"5","key":"e_1_3_2_3_1","first-page":"1217","article-title":"A comparison of phospholipase activity, cellular adherence and pathogenicity of yeasts","volume":"131","author":"Barret-Bee K","year":"2009","unstructured":"Barret-Bee K, Hayes Y, Wilson RG, Ryley JF. 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