{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:56:00Z","timestamp":1791608160839,"version":"4.3.4"},"reference-count":42,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T00:00:00Z","timestamp":1626912000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T00:00:00Z","timestamp":1626912000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Department of Surgery at the University Hospital of Basel","award":["2019"],"award-info":[{"award-number":["2019"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Common surgical techniques aim to turn the entire vomerine mucosa with vomer flaps either to the oral side or to the nasal side. The latter approach is widely performed due to the similarity in color to the nasal mucosa. However, we lack a histologic description of the curved vomerine mucosa in cleft lip and palate malformations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We histologically examined an excess of curved vomerine mucosa in 8 patients using hematoxylin\u2013eosin, periodic acid\u2013Schiff, Elastin van Gieson, and Alcian blue stains. Tissue samples were obtained during surgery at 8 months of age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Our histological analysis of the mucoperiosteum overlying the curved vomer revealed characteristics consistent with those of an oral mucosa or a squamous metaplasia of the nasal mucosa, as exhibited by a stratified squamous epithelium containing numerous seromucous glands. Some areas showed a palisaded arrangement of the basal cells compatible with metaplasia of respiratory epithelium, but no goblet cells or respiratory cilia were identified. Abundant fibrosis and rich vascularity were present.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The vomer mucosa showed no specific signs of nasal mucosa. These findings should be considered in presurgical cleft orthopedics and palatal surgery for further refinement. Shifting the vomer mucosa according to a fixed physiologic belief should not overrule other important aspects of cleft repair such as primary healing and establishing optimal form and function of palatal roof and nasal floor.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10556656211031419","type":"journal-article","created":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T05:30:21Z","timestamp":1626931821000},"page":"1048-1055","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Histologic Aspect of the Curved Vomerine Mucosa in Cleft Lip and Palate"],"prefix":"10.1177","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4459-6603","authenticated-orcid":false,"given":"Benito K.","family":"Benitez","sequence":"first","affiliation":[{"name":"Department of Oral and Craniomaxillofacial Surgery, University Hospital Basel and University of Basel, Switzerland"},{"name":"Department of Clinical Research, University of Basel, Switzerland"},{"name":"Department of Biomedical Engineering, University of Basel, Allschwil, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9042-1842","authenticated-orcid":false,"given":"Andrzej","family":"Brudnicki","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Surgery, Clinic of Pediatric Surgery, Institute of Mother and Child, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasad","family":"Nalabothu","sequence":"additional","affiliation":[{"name":"Department of Oral and Craniomaxillofacial Surgery, University Hospital Basel and University of Basel, Switzerland"},{"name":"Department of Clinical Research, University of Basel, Switzerland"},{"name":"Department of Biomedical Engineering, University of Basel, Allschwil, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeannette A. von","family":"Jackowski","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of Basel, Allschwil, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Bruder","sequence":"additional","affiliation":[{"name":"Pathology, Institute of Medical Genetics and Pathology, University Hospital Basel and University of Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas Albert","family":"Mueller","sequence":"additional","affiliation":[{"name":"Department of Oral and Craniomaxillofacial Surgery, University Hospital Basel and University of Basel, Switzerland"},{"name":"Department of Clinical Research, University of Basel, Switzerland"},{"name":"Department of Biomedical Engineering, University of Basel, Allschwil, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,7,22]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1055665620944757"},{"key":"e_1_3_4_3_1","first-page":"370","volume-title":"Facial Clefts Craniosynostosis Principles and Management","author":"Abyholm FE","year":"1996","unstructured":"Abyholm FE. 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