{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:33:18Z","timestamp":1777523598828,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T00:00:00Z","timestamp":1635897600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2022,12]]},"abstract":"\n Objectives<\/jats:title>\n \n Non-syndromic cleft lip with or without cleft palate (NSCL\u2009\u00b1\u2009\n P<\/jats:italic>\n ) is one of the most common birth malformations. Currently, numerous susceptibility SNPs have been reported by GWA studies, however, the replications of them among NSCL\u2009\u00b1\u2009\n P<\/jats:italic>\n from Han Chinese were very limited.\n <\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n \n In this study, we selected 16 SNPs around 1q32.2 based on the published GWA studies and replicated them among 302 trios with NSCL\u2009\u00b1\u2009\n P<\/jats:italic>\n from Han Chinese Population. The genotypic data was analyzed with FBAT, PLINK and R package.\n <\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n The study was conducted in a tertiary medical center.<\/jats:p>\n <\/jats:sec>\n \n Patients, participants<\/jats:title>\n \n 302 patients with CL\u2009\u00b1\u2009\n P<\/jats:italic>\n and their parents.\n <\/jats:p>\n <\/jats:sec>\n \n Main outcome measures<\/jats:title>\n \n To ascertain the genetic variants in 1q32.2 in patients with CL\u2009\u00b1\u2009\n P<\/jats:italic>\n in Han Chinese Population.\n <\/jats:p>\n <\/jats:sec>\n \n Interventions<\/jats:title>\n Blood samples were collected.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n We found T allele (\n Z<\/jats:italic>\n \u2009=\u20094.26,\n p<\/jats:italic>\n \u2009=\u20090.00002) and T\/T homozygotes (\n Z<\/jats:italic>\n \u2009=\u20094.4,\n p<\/jats:italic>\n \u2009=\u20090.000011) at rs12063989 was significantly over-transmitted among non-syndromic cleft lip with or without cleft palate (NSCL\u2009\u00b1\u2009\n P<\/jats:italic>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n We found rs12063989 exhibited significant association with the occurrence of NSCL\u2009\u00b1\u2009\n P<\/jats:italic>\n , which would provide new evidence for the future study in the etiology of NSCL\u2009\u00b1\u2009\n P<\/jats:italic>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/10556656211052837","type":"journal-article","created":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T10:56:24Z","timestamp":1635936984000},"page":"1520-1526","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between SNPs in 1q32.2 and NSCL\u2009\u00b1\u2009\n P<\/i>\n in Han Chinese Population"],"prefix":"10.1177","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1279-3170","authenticated-orcid":false,"given":"Bin","family":"Yin","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of cleft lip and palate, West China Hospital of Stomatology, Sichuan University, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-Yu","family":"Shi","sequence":"additional","affiliation":[{"name":"Division of Growth and Development and Section of Orthodontics, School of Dentistry, University of California, Los Angeles, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Shi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of cleft lip and palate, West China Hospital of Stomatology, Sichuan University, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Zheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of cleft lip and palate, West China Hospital of Stomatology, Sichuan University, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhong-Lin","family":"Jia","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of cleft lip and palate, West China Hospital of Stomatology, Sichuan University, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,11,3]]},"reference":[{"key":"e_1_3_3_2_1","first-page":"676","article-title":"Transmission-disequilibrium tests for quantitative traits","volume":"60","author":"Allison DB","year":"1997","unstructured":"Allison DB. 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