{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:12:33Z","timestamp":1791389553326,"version":"4.3.3"},"reference-count":35,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T00:00:00Z","timestamp":1638748800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T00:00:00Z","timestamp":1638748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The ideal surgical protocol and technique for primary closure of unilateral cleft lip and palate (UCLP) are unclear, and the development of velopharyngeal insufficiency and fistulae following primary repair is common. This study aimed to determine the long-term surgical burden of care in terms of secondary surgeries, defined as speech-correcting surgeries (SCSs) and fistula repair, in a UCLP population, and to compare outcomes of various surgical protocols.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective, single-center review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>The study comprised 290 nonsyndromic children with complete UCLP. Different surgical protocols entailing both single-stage and 2-stage approaches were compared, and the surgical outcome was analyzed at the time of alveolar bone grafting (ABG) and post ABG.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Altogether 110 children (37.9%) underwent secondary surgery by the time of ABG. Of the total population 25.9% (n\u2009\u2009=\u2009\u200975) had undergone SCS and 17.2% (n\u2009\u2009=\u2009\u200950) had undergone fistula repair. The respective incidences at follow-up (post ABG) were 30.3% (n\u2009\u2009=\u2009\u200988) and 18.9% (n\u2009\u2009=\u2009\u200955). Median age at ABG was 9.8 years and at follow-up was 16.3 years. No significant difference emerged in terms of secondary surgeries between the techniques and protocols applied at primary repair. However, some differences occurred regarding the location of fistulae; the single-stage procedure had more anterior fistula repairs, particularly connected to a perialveolar fistula.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although the outcome differences between the surgical protocols were small, indicating that none of the treatment protocols was clearly superior to another, attention was drawn to the favorable outcomes of the single-stage protocol.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10556656211055641","type":"journal-article","created":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T05:50:09Z","timestamp":1638769809000},"page":"1537-1545","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Long-Term Follow-up of Unilateral Cleft lip and Palate: Incidence of Speech-Correcting Surgeries and Fistula Formation"],"prefix":"10.1177","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9527-4180","authenticated-orcid":false,"given":"Charlotta","family":"Gustafsson","sequence":"first","affiliation":[{"name":"Cleft Palate and Craniofacial Center, Helsinki University and Helsinki University Hospital, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8064-3484","authenticated-orcid":false,"given":"Arja","family":"Heli\u00f6vaara","sequence":"additional","affiliation":[{"name":"Cleft Palate and Craniofacial Center, Helsinki University and Helsinki University Hospital, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junnu","family":"Leikola","sequence":"additional","affiliation":[{"name":"Cleft Palate and Craniofacial Center, Helsinki University and Helsinki University Hospital, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,12,6]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-0358.57197"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000006242"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1071-0949(06)80034-X"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001665-200409000-00020"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1597\/11-190"},{"issue":"4","key":"e_1_3_2_7_1","first-page":"1285","article-title":"Early hard palate closure using a vomer flap in unilateral cleft lip and palate: effects on cleft width","volume":"18","author":"de Jong JP","year":"2014","unstructured":"de Jong JP, Breugem CC. 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