{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T01:53:58Z","timestamp":1782179638067,"version":"3.54.5"},"reference-count":38,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T00:00:00Z","timestamp":1637107200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Hebei Provincial Medical Science Research Project","award":["20200451"],"award-info":[{"award-number":["20200451"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Non syndromic cleft lip with or without palate (NSCL\/P), one of the most common birth defects, is closely related to various risk factors. However, information regarding risk factors for NSCL\/P in rural districts in China is very limited thus far. The objective of this study was designed to identify the potential risk factors for NSCL\/P in rural districts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>A comprehensive retrospective investigation including 435 NSCL\/P patients and 402 healthy children was carried out in Hebei Province, China. Multiple logistic regression analysis and transmission disequilibrium test (TDT) were respectively used to identify non-genetic and genetic risk factors for NSCL\/P, and then PLINK was used to explore the relationship between non-genetic and genetic risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>The results showed that maternal periconceptional exposure to pesticides and herbicides, as well as low parental education level were involved in the increased risk of NSCL\/P, whereas maternal folic acid and multivitamin supplementation use during preconception period were associated with the reduced risk of NSCL\/P. TDT analysis identified 2 single nucleotide polymorphisms (SNPs) (rs7078160 and rs4752028) in VAX1 and one SNP (rs17563) in BMP4 as the genetic risk factors for NSCL\/P. Further analysis showed that the genetic risk factors were closely related with the negative non-genetic risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>Our study identified the potential risk factors for NSCL\/P in rural districts, thus providing a theoretical basis for the prevention of NSCL\/P occurrence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10556656211058833","type":"journal-article","created":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T09:27:13Z","timestamp":1637141233000},"page":"211-218","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["A Comprehensive Investigation on Potential Risk Factors for NSCL\/P in a Rural District of Hebei Province, China"],"prefix":"10.1177","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6027-6338","authenticated-orcid":false,"given":"Congna","family":"Chai","sequence":"first","affiliation":[{"name":"Department of Stomatology, Handan Central Hospital, Handan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Handan Central Hospital, Handan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Jiao","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Handan Central Hospital, Handan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Dang","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Handan Stomatological Hospital, \rHandan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubin","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Handan Central Hospital, Handan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,11,17]]},"reference":[{"key":"bibr1-10556656211058833","doi-asserted-by":"publisher","DOI":"10.1038\/ng.580"},{"key":"bibr2-10556656211058833","doi-asserted-by":"publisher","DOI":"10.1038\/ng.333"},{"key":"bibr3-10556656211058833","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.35749"},{"key":"bibr4-10556656211058833","doi-asserted-by":"publisher","DOI":"10.1542\/peds.104.6.e66"},{"issue":"10","key":"bibr5-10556656211058833","first-page":"2576","volume":"13","author":"Duan S","year":"2020","journal-title":"Int J Clin Exp 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