{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T05:05:41Z","timestamp":1789103141547,"version":"build-2803163510"},"reference-count":23,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T00:00:00Z","timestamp":1616112000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Cartilage grafts are widely used in reconstructing nasal deformity for structural and aesthetic purposes. Despite being immunologically privileged, cartilage grafts are susceptible to volume loss with high risk of resorption over time. Therefore, experts opt for cartilage handling modification to resolve this issue through graft dicing, wrapping, or perichondrium preservation. This study will evaluate the effect cartilage graft preparations on graft viability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Single-randomized post-test-only study design.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting:<\/jats:title>\n                    <jats:p>Animal Hospital at Bogor Agricultural Institute.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants:<\/jats:title>\n                    <jats:p>Six New Zealand, male, Hycole rabbits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Intervention:<\/jats:title>\n                    <jats:p>Conchal cartilage grafts were retrieved from 6 experimental rabbits and distributed into 3 treatment groups: diced cartilage graft (DC; control), one-sided perichondrium-attached scored cartilage (OPSC), and tube-shaped perichondrium-wrapped diced cartilage (TPDC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures:<\/jats:title>\n                    <jats:p>Macroscopic (weight and contour) and microscopic (chondroblast proliferation, graft thickness, apoptotic cells) evaluation through histological measures were recorded on week 12. Statistical analysis was done to compare between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Diced cartilage and OPSC groups showed significant weight changes on week 12 (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .05) with OPSC presenting with the biggest difference. Diced cartilage and OPSC group showed moderate cell proliferation on week 12 while TPDC displayed most abundant apoptotic cells (5.8%;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .05). Diced cartilage group had the highest cartilage thickness ratio (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>Bare DC technique promoted graft thickness while perichondrium-attached scored cartilage showed the most abundant chondroblast proliferation and the least apoptotic cells. Perichondrium contributes to enhanced new cartilage formation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Diced cartilage graft is suitable for masking irregularity and volume augmentation, while perichondrium-attached cartilage graft is better for structural support in nasal reconstruction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1055665621998173","type":"journal-article","created":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T04:54:30Z","timestamp":1616129670000},"page":"149-155","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["The Effect of Perichondrium and Graft Modification on the Viability of Conchal Cartilage Graft: An Experimental Study in Rabbit"],"prefix":"10.1177","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2739-8111","authenticated-orcid":false,"given":"Nathania Pudya","family":"Hapsari","sequence":"first","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Department of Surgery, Cleft and Craniofacial Center, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6312-9261","authenticated-orcid":false,"given":"Kristaninta","family":"Bangun","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Department of Surgery, Cleft and Craniofacial Center, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parintosa","family":"Atmodiwirjo","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Department of Surgery, Cleft and Craniofacial Center, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bambang","family":"Ponco","sequence":"additional","affiliation":[{"name":"Department of Pathology Anatomy, Faculty of Veterinary Medicine, Bogor Agricultural University, Bogor, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tri Isyani Tungga","family":"Dewi","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Veterinary Teaching Hospital, Bogor Agricultural University, Bogor, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5784-3154","authenticated-orcid":false,"given":"Jessica","family":"Halim","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Department of Surgery, Cleft and Craniofacial Center, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,3,19]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2006.02.005"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000004333"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-011-9725-9"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2010.03.013"},{"key":"e_1_3_3_6_1","volume-title":"Statpearls. Statpearls Publishing","author":"Chang L","year":"2020","unstructured":"Chang L, Marston G, Martin A. Anatomy, cartilage. In: Statpearls. Statpearls Publishing; 2020."},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.asj.2006.01.006"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-200209150-00011"},{"issue":"4","key":"e_1_3_3_9_1","first-page":"1145","article-title":"Fate of implanted autologus cartilage grafts in rabbits: an experimental histological study","volume":"42","author":"Elwany MS","year":"2006","unstructured":"Elwany MS, Radi SH, Foda HT, Magdy E, Kalsa RR. Fate of implanted autologus cartilage grafts in rabbits: an experimental histological study. Bull Alex Fac Med. 2006;42(4):1145\u20131157.","journal-title":"Bull Alex Fac Med"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-200005000-00051"},{"key":"e_1_3_3_11_1","volume-title":"Experimental Design: Theory and Application","author":"Federer WT","year":"1967","unstructured":"Federer WT. Experimental Design: Theory and Application. Oxford & Ibh Publishing Company; 1967."},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0b013e31822f3b1f"},{"issue":"2","key":"e_1_3_3_13_1","first-page":"83","article-title":"Resorption of cartilage grafts in rhinoplasty: fundamental basis","volume":"131","author":"Gabory LD","year":"2010","unstructured":"Gabory LD, Fricain JC, Stoll D. Resorption of cartilage grafts in rhinoplasty: fundamental basis. Rev Laryngol Otol Rhinol (Bord). 2010;131(2):83\u201388.","journal-title":"Rev Laryngol Otol Rhinol (Bord)"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/1090820X12455635"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsc.2010.10.006"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000244880.12256.7c"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-014-3192-2"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-014-0403-6"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/archfaci.8.1.42"},{"key":"e_1_3_3_20_1","first-page":"137","article-title":"Zur deckung von defekten der nasenfl\u00fcgel","volume":"39","author":"Koenig F","year":"1902","unstructured":"Koenig F. Zur deckung von defekten der nasenfl\u00fcgel. Berl Klein Wochenschr. 1902;39:137.","journal-title":"Berl Klein Wochenschr"},{"issue":"1","key":"e_1_3_3_21_1","first-page":"52","article-title":"A comparison in graft resorption between three techniques of diced cartilage using surgical blade, electrical grinder and grater in rabbit","volume":"3","author":"Manafi A","year":"2014","unstructured":"Manafi A, Sabet M, Emami A, Vasei M, Mosavi J, Hamedi ZS, Manafi F, Mehrabani G, Manafi N. A comparison in graft resorption between three techniques of diced cartilage using surgical blade, electrical grinder and grater in rabbit. World J Plast Surg. 2014;3(1):52\u201363.","journal-title":"World J Plast Surg"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12070-015-0935-3"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-019-01581-5"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.3109\/08941939.2013.778922"}],"container-title":["The Cleft Palate Craniofacial Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1055665621998173","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1055665621998173","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1055665621998173","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:21:44Z","timestamp":1777393304000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1055665621998173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,19]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1177\/1055665621998173"],"URL":"https:\/\/doi.org\/10.1177\/1055665621998173","relation":{},"ISSN":["1055-6656","1545-1569"],"issn-type":[{"value":"1055-6656","type":"print"},{"value":"1545-1569","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,19]]}}}