{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T14:53:18Z","timestamp":1781275998203,"version":"3.54.1"},"reference-count":33,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2022,7,3]],"date-time":"2022-07-03T00:00:00Z","timestamp":1656806400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","award":["EP\/N02124X\/1"],"award-info":[{"award-number":["EP\/N02124X\/1"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Great Ormond Street Hospital for Children Charity","award":["12GS15"],"award-info":[{"award-number":["12GS15"]}]},{"name":"Great Ormond Street Hospital for Children Charity","award":["17DD46"],"award-info":[{"award-number":["17DD46"]}]},{"name":"GOSH Biomedical Research Centre","award":["17DS18"],"award-info":[{"award-number":["17DS18"]}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["ERC-2017-StG-757923"],"award-info":[{"award-number":["ERC-2017-StG-757923"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the relationship between perception of craniofacial deformity, geometric head features, and 3D head shape analyzed by statistical shape modeling (SSM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients<\/jats:title>\n                    <jats:p>A total of 18 unoperated patients with scaphocephaly (age\u2009\u2009=\u2009\u20095.2\u2009\u2009\u00b1\u2009\u20091.1m)\u20146 were followed-up after spring-assisted cranioplasty (SAC) (age\u2009\u2009=\u2009\u20099.6\u2009\u2009\u00b1\u2009\u20091.5m)\u2014and 6 controls (age\u2009\u2009=\u2009\u20096.7\u2009\u2009\u00b1\u2009\u20092.5m).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>3D head shapes were retrieved from 3D scans or computed tomography (CTs). Various geometrical features were measured: anterior and posterior prominence, take-off angle, average anterior and posterior lateral and horizontal curvatures, cranial index (CI) (cranial width over length), and turricephaly index (TI) (cranial height over length). SSM and principal component analysis (PCA) described shape variability. All models were 3D printed; the perception of deformity was blindly scored by 9 surgeons and 1 radiologist in terms of frontal bossing (FB), occipital bulleting (OB), biparietal narrowing (BN), low posterior vertex (LPV), and overall head shape (OHS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A moderate correlation was found between FB and anterior prominence (r\u2009\u2009=\u2009\u20090.56, P\u2009&lt;\u2009.01) and take-off angle (r\u2009\u2009=\u2009\u2009\u2212 0.57, P\u2009&lt;\u2009.01). OB correlated with average posterior lateral curvature (r\u2009\u2009=\u2009\u20090.43, P\u2009&lt;\u20090.01) similarly to BPN (r\u2009\u2009=\u2009\u20090.55, P\u2009&lt;\u2009.01) and LPV (r\u2009\u2009=\u2009\u20090.43, P\u2009&lt;\u2009.01). OHS showed strong correlation with CI (r\u2009\u2009=\u2009\u2009\u2009\u2212\u20090.68, P\u2009&lt;\u2009.01) and TI (r\u2009\u2009=\u2009\u20090.63, P&lt;\u2009.01). SSM Mode 1 correlated with OHS (r\u2009\u2009=\u2009\u20090.66, p\u2009&lt;\u2009.01) while Mode 3 correlated with FB (r\u2009\u2009=\u2009\u2009\u2009\u2212\u20090.58, P\u2009&lt;\u2009.01).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Esthetic cranial appearance in craniofacial patients is correlated to specific geometric parameters and could be estimated using automated methods such as SSM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10556656221111307","type":"journal-article","created":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T01:34:40Z","timestamp":1656898480000},"page":"1591-1599","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["The Esthetic Perception of Morphological Severity in Scaphocephalic Patients is Correlated With Specific Head Geometrical Features"],"prefix":"10.1177","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1514-1979","authenticated-orcid":false,"given":"Alessandro","family":"Borghi","sequence":"first","affiliation":[{"name":"UCL Great Ormond Street Institute of Child Health, London, UK"},{"name":"Great Ormond Street Hospital for Children, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Heutinck","sequence":"additional","affiliation":[{"name":"UCL Great Ormond Street Institute of Child Health, London, UK"},{"name":"Erasmus University Hospital, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Rodriguez-Florez","sequence":"additional","affiliation":[{"name":"Universidad de Navarra, TECNUN Escuela de Ingenieros, Donostia-San Sebasti\u00e1n, Spain"},{"name":"Ikerbasque, Basque Foundation for Science, Bilbao, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Koudstaal","sequence":"additional","affiliation":[{"name":"UCL Great Ormond Street Institute of Child Health, London, UK"},{"name":"Great Ormond Street Hospital for Children, London, UK"},{"name":"Erasmus University Hospital, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5184-5271","authenticated-orcid":false,"given":"F.","family":"Ruggiero","sequence":"additional","affiliation":[{"name":"Great Ormond Street Hospital for Children, London, UK"},{"name":"DIBIDEM, Alma Mater Studiorum University of Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Ajami","sequence":"additional","affiliation":[{"name":"UCL Great Ormond Street Institute of Child Health, London, UK"},{"name":"Great Ormond Street Hospital for Children, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Schievano","sequence":"additional","affiliation":[{"name":"UCL Great Ormond Street Institute of Child Health, London, UK"},{"name":"Great Ormond Street Hospital for Children, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.U.O.","family":"Jeelani","sequence":"additional","affiliation":[{"name":"UCL Great Ormond Street Institute of Child Health, London, UK"},{"name":"Great Ormond Street Hospital for Children, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Dunaway","sequence":"additional","affiliation":[{"name":"UCL Great Ormond Street Institute of Child Health, London, UK"},{"name":"Great Ormond Street Hospital for Children, London, 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Population-derived material properties for Craniosynostosis patients improve outcome predictions in Craniofacial Surgery. 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