{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:25:43Z","timestamp":1777523143583,"version":"3.51.4"},"reference-count":45,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T00:00:00Z","timestamp":1658793600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Palate development involves a genetic regulation through a complex molecular mechanism that may be disrupted by environmental factors, resulting in impaired fusion and cleft palate formation. An encounter with a case of cleft palate due to dorsal tongue hamartoma prompted us to perform this systematic review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To review the clinical profile and management approach for a case with cleft palate and tongue hamartoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A systematic literature search was conducted using keywords related to cleft palate and tongue hamartoma in PubMed, Scopus, MEDLINE, and Scielo databases through December 2021, with no time or language restrictions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients, Participants<\/jats:title>\n                    <jats:p>Studies reporting patients with cleft palate and tongue hamartoma were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcome measure(s)<\/jats:title>\n                    <jats:p>Information related to clinical profile, diagnostic tests, histopathology, management, and outcomes were extracted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>Fourteen relevant publications were identified with 16 cases reported so far. Among them, thirteen patients were females (81.25%), and 3 were males (18.75%). The age of presentation varied from birth to 19 years. Oral-facial-digital syndrome (type II) was the most commonly associated syndrome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>Congenital tongue hamartoma with cleft palate is a rare presentation, which can present as an isolated entity or part of a syndrome. Genetic evaluation is warranted, particularly for multiple hamartomatous lesions. The preferred treatment is immediate excision of hamartoma while following a standard timeline for palatoplasty.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10556656221116001","type":"journal-article","created":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T12:41:24Z","timestamp":1658839284000},"page":"1609-1618","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A Rare Case of Cleft Palate Associated With Tongue Hamartoma: A Case Report and Systematic Review"],"prefix":"10.1177","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4323-6147","authenticated-orcid":false,"given":"Suvashis","family":"Dash","sequence":"first","affiliation":[{"name":"Department of Plastic Reconstructive & Burns Surgery, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7829-2192","authenticated-orcid":false,"given":"Shashank","family":"Chauhan","sequence":"additional","affiliation":[{"name":"Department of Plastic Reconstructive & Burns Surgery, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6926-3691","authenticated-orcid":false,"given":"Karthik","family":"Sennimalai","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Dentofacial Deformities, Centre for Dental Education and Research, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Om Prakash","family":"Kharbanda","sequence":"additional","affiliation":[{"name":"Department of Plastic Reconstructive & Burns Surgery, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9161-2501","authenticated-orcid":false,"given":"Maneesh","family":"Singhal","sequence":"additional","affiliation":[{"name":"Department of Plastic Reconstructive & Burns Surgery, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,7,26]]},"reference":[{"key":"bibr1-10556656221116001","doi-asserted-by":"publisher","DOI":"10.1179\/bjo.8.3.115"},{"key":"bibr2-10556656221116001","doi-asserted-by":"publisher","DOI":"10.4161\/org.7.4.17926"},{"key":"bibr3-10556656221116001","first-page":"223","volume-title":"Grabb and Smith\u2019s Plastic Surgery","author":"Gosain AK","year":"1997","edition":"5"},{"issue":"2","key":"bibr4-10556656221116001","first-page":"225","volume":"36","author":"Greene RM","year":"1976","journal-title":"J Embryol Exp Morphol"},{"key":"bibr5-10556656221116001","first-page":"515","volume-title":"Plastic Surgery","volume":"3","author":"Afshar M","year":"2013","edition":"3"},{"key":"bibr6-10556656221116001","doi-asserted-by":"publisher","DOI":"10.1016\/bs.ctdb.2015.07.002"},{"key":"bibr7-10556656221116001","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2016.00067"},{"key":"bibr8-10556656221116001","volume-title":"Zur Entwicklungsgeschichte des Kopfes des Menschen und der h\u00f6heren Wirbelthiere: Mit Holzschnitten und einem Atlas von neun Kupfertafeln mit erkl\u00e4rendem Texte","author":"Dursy E","year":"1869"},{"key":"bibr9-10556656221116001","unstructured":"His W. 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