{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T16:00:36Z","timestamp":1784908836833,"version":"3.55.0"},"reference-count":33,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T00:00:00Z","timestamp":1660694400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005156","name":"Alexander von Humboldt-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>The maxilla is formed by the medial nasal and maxillary processes fusion. The dental lamina develops from 2 origins connecting in the lateral incisor. The maxillary lateral incisor region is often affected by dental anomalies and clefting. It is possible that genes involved in oral cleft could also be associated with a variety of phenotypic variations in the maxillary lateral incisor. In this phenotype\u2013genotype study, we explored the association between polymorphisms in the oral-cleft-related genes BMP2 and BMP4 and root curvature of maxillary lateral incisors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>Cross-sectional study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>Universities and private clinics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>Panoramic radiographs and DNA from 231 patients were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>Schneider method (1971) was applied to estimate the degree of root curvature of the maxillary lateral incisors and to classify the root as straight (5\u00b0 or less) or curved (higher than 5\u00b0). Genetic polymorphisms in BMP2 (rs235768 and rs1005464) and BMP4 (rs17563) were genotyped. Statistical analysis was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>A total of 401 teeth (199 left and 202 right) were evaluated. Genetic analysis demonstrated trends toward association for the rs1005464 in BMP2 ( P\u2009\u2009=\u2009\u2009.025) in co-dominant model and in dominant model ( P\u2009\u2009=\u2009\u2009.026) for left incisors. The rs235768 in BMP2 showed trends toward association with the degree of root curvature in left incisors in the recessive model ( P\u2009\u2009=\u2009\u2009.031). rs17563 in BMP4 also showed trends toward association with the degree of the root curvature in left incisors ( P\u2009\u2009=\u2009\u2009.019).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>BMP2 (rs235768 and rs1005464) and BMP4 (rs17563) might be involved in maxillary lateral incisor root curvature.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10556656221121062","type":"journal-article","created":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T02:37:51Z","timestamp":1660790271000},"page":"177-183","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Oral Cleft Related-Genes may be Involved in Root Curvature of Maxillary Lateral Incisors"],"prefix":"10.1177","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5351-2526","authenticated-orcid":false,"given":"Erika Calvano","family":"K\u00fcchler","sequence":"first","affiliation":[{"name":"Department of Orthodontics, University of Regensburg, Regensburg, Germany"},{"name":"School of Dentistry, Tuiuti University from Paran\u00e1, Curitiba, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeferson Luis","family":"de Oliveira Stroparo","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Univille \u2013 University from the Joinville Region, Joinville, Santa Catarina, Brazil"},{"name":"Cesumar Curitiba Dental School, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caio Luiz","family":"Bitencourt Reis","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, School of Dentistry of Ribeir\u00e3o Preto, USP - University of S\u00e3o Paulo, Ribeir\u00e3o Preto, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas","family":"Ullrich","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, University of Regensburg, Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernardo","family":"Olsson","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Federal University of Paran\u00e1, Curitiba, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4911-6413","authenticated-orcid":false,"given":"Rafaela","family":"Scariot","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Federal University of Paran\u00e1, Curitiba, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirian Nakane","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, School of Dentistry of Ribeir\u00e3o Preto, USP - University of S\u00e3o Paulo, Ribeir\u00e3o Preto, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natanael Henrique","family":"Ribeiro Mattos","sequence":"additional","affiliation":[{"name":"School of Dentistry, Tuiuti University from Paran\u00e1, Curitiba, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Proff","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, University of Regensburg, Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5649-7234","authenticated-orcid":false,"given":"Flares","family":"Baratto-Filho","sequence":"additional","affiliation":[{"name":"School of Dentistry, Tuiuti University from Paran\u00e1, Curitiba, Paran\u00e1, Brazil"},{"name":"Department of Dentistry, Univille \u2013 University from the Joinville Region, Joinville, Santa Catarina, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Kirschneck","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, University of Regensburg, Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,8,17]]},"reference":[{"key":"bibr1-10556656221121062","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2011.03.002"},{"key":"bibr2-10556656221121062","doi-asserted-by":"publisher","DOI":"10.3109\/00016358109162264"},{"issue":"4","key":"bibr3-10556656221121062","first-page":"244","volume":"15","author":"Stamatiou J","year":"1991","journal-title":"J Clin Pediatr 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