{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T17:50:22Z","timestamp":1785261022540,"version":"3.55.0"},"reference-count":41,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T00:00:00Z","timestamp":1670198400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Published literature on children with cleft palate and\/or lip (CP\u2009+\u2009\/-L) and CHARGE syndrome (CS) is limited. This study investigated cleft characteristics including surgery, and feeding and communication outcomes in children identified with CP\u2009+\u2009\/-L and CS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective cross-sectional review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Regional Referral Centre for Paediatric Cleft Surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients<\/jats:title>\n                    <jats:p>All children diagnosed with CP\u2009+\u2009\/-L and CS (based on clinical features and\/or CHD7 mutation testing) between 1989\u20132019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>Cleft type, timing of CP\u2009+\u2009\/-L repair, reasons for \u2018delayed\u2019 repair, feeding methods and communication modality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty-two children with CP\u2009+\u2009\/-L and CS were identified. Cleft sub-types (%) were: Eleven (50%) had bilateral cleft lip and palate (BCLP), six (27%) had unilateral cleft lip and palate (UCLP) and five (23%) had cleft palate (CP). Cleft repair was delayed compared to protocol care for non-syndromic children with CP\u2009+\u2009\/-L. Median age for lip repair\u2009+\u2009\/- vomerine flap was 9 months (range 4\u201322 months), and palate repair was 21 months (range 11\u201340 months). Median age for isolated CP repair was 13 months (range 7\u201323). Surgery for cardiac anomalies (36%) before cleft repair, and (59%) were classed as having severe systemic disease at the time of cleft surgery. Only 27% of the children in this study had both full oral feeding and verbal communication.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Children with CP\u2009+\u2009\/-L and CS had severe cleft types and complex medical problems leading to delayed cleft surgery. Feeding and speech outcomes were better in the children aged over ten years.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10556656221134558","type":"journal-article","created":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T00:03:21Z","timestamp":1670285001000},"page":"620-630","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["The Incidence and Outcomes for Children with Cleft Palate and\/or Lip and CHARGE Syndrome"],"prefix":"10.1177","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1747-2269","authenticated-orcid":false,"given":"Mohammed","family":"Farid","sequence":"first","affiliation":[{"name":"West Midlands Cleft Centre, Birmingham Children's Hospital, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Cafferky","sequence":"additional","affiliation":[{"name":"West Midlands Cleft Centre, Birmingham Children's Hospital, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Kirk","sequence":"additional","affiliation":[{"name":"Department of Paediatric Endocrinology, Birmingham Children's Hospital, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Kershaw","sequence":"additional","affiliation":[{"name":"Department of Paediatric Endocrinology, Birmingham Children's Hospital, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1956-6066","authenticated-orcid":false,"given":"Rona","family":"Slator","sequence":"additional","affiliation":[{"name":"West Midlands Cleft Centre, Birmingham Children's Hospital, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,12,5]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(79)80513-2"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3928\/0191-3913-19790301-10"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/000992289803700302"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22086"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.30560"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.99.3.363"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2010.087106"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1993.01880130051006"},{"key":"e_1_3_2_10_2","unstructured":"CRANE 2019 (The cleft registry and audit network) the Royal College of Surgeons (England). 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