{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T07:25:25Z","timestamp":1791617125410,"version":"4.3.4"},"reference-count":32,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T00:00:00Z","timestamp":1708473600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Ms. Gamarra was funded by the Medical Student Research Scholarship (MDSRS)\/Samuel J. Roessler Memorial Scholarship at The Ohio State University College of Medicine"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2025,6]]},"abstract":"\n Objective<\/jats:title>\n To investigate health-related quality of life (HRQL) in children aged 2 to 7 years, who have undergone surgery for craniosynostosis.<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Cross-sectional survey.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n A tertiary pediatric academic medical center.<\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n Children with craniosynostosis who underwent surgical correction, and who were 2\u20137 years old at the time of the study. Children from families that did not speak English were excluded.<\/jats:p>\n <\/jats:sec>\n \n Interventions<\/jats:title>\n Caregivers were asked to fill out the Pediatric Quality of Life Inventory (PedsQL) Core Parent Report and the PedsQL Cognitive Functioning Scale.<\/jats:p>\n <\/jats:sec>\n \n Main outcome measures<\/jats:title>\n \n \n \n PedsQL: Psychosocial Health Summary Score, Physical Health Summary Score, Total Core Score, Cognitive Functioning Scale Score. Scores range from 0 to 100, with higher scores reflecting greater QoL<\/jats:p>\n <\/jats:list-item>\n \n Subject factors: comorbidities, syndromic status, type of craniosynostosis, type of surgery<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n The study included 53 subjects, of whom 13.2% had a syndrome. Core and cognitive scores did not depend on presence of a syndrome or suture involved. Subjects who underwent posterior cranial distraction achieved higher Total Core Scores than subjects who underwent open vault remodeling. Among subjects with sagittal craniosynostosis, there was a tendency for higher scores among children who underwent minimally-invasive surgery compared to those who underwent open vault remodeling.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n This study demonstrates similar HRQL among children with and without a syndrome, higher HRQL among children undergoing posterior cranial distraction than those undergoing open vault remodeling, and trends towards higher HRQL in children with sagittal craniosynostosis who underwent minimally-invasive surgery compared to those who underwent open vault remodeling.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/10556656241234562","type":"journal-article","created":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T08:23:45Z","timestamp":1708503825000},"page":"970-975","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Prospective Evaluation of Health-Related Quality-of-Life in Children with Craniosynostosis"],"prefix":"10.1177","volume":"62","author":[{"given":"Valeria","family":"Gamarra","sequence":"first","affiliation":[{"name":"The Ohio State University College of Medicine, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory D.","family":"Pearson","sequence":"additional","affiliation":[{"name":"The Ohio State University College of Medicine, Columbus, OH, USA"},{"name":"Department of Plastic and Reconstructive Surgery, Nationwide Children's Hospital, Columbus, OH, USA"},{"name":"Department of Plastic and Reconstructive Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Drapeau","sequence":"additional","affiliation":[{"name":"Section of Neurosurgery, Health Sciences Centre and University of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Pindrik","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Nationwide Children's Hospital, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0040-6396","authenticated-orcid":false,"given":"Canice E.","family":"Crerand","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Nationwide Children's Hospital, Columbus, OH, USA"},{"name":"Center for Biobehavioral Health, Nationwide Children's Hospital, Columbus, OH, USA"},{"name":"Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0209-4656","authenticated-orcid":false,"given":"Ari N.","family":"Rabkin","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Nationwide Children's Hospital, Columbus, OH, USA"},{"name":"Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, USA"},{"name":"Division of Psychology and Neuropsychology, Nationwide Children's Hospital, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7978-6792","authenticated-orcid":false,"given":"Ibrahim","family":"Khansa","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Nationwide Children's Hospital, Columbus, OH, USA"},{"name":"Department of Plastic and Reconstructive Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA"},{"name":"Division of Plastic Surgery, Texas Children's Hospital \u2013 North Austin, Austin, TX, USA"},{"name":"Baylor College of Medicine, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,2,21]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0000000000001383"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2021.110873"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2020.08.102"},{"key":"e_1_3_2_5_2","first-page":"1382","article-title":"The craniectomy in microcephaly","volume":"110","author":"Lannelongue M","year":"1890","unstructured":"Lannelongue M. 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