{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T12:02:13Z","timestamp":1789387333214,"version":"build-2803163510"},"reference-count":37,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T00:00:00Z","timestamp":1718236800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T00:00:00Z","timestamp":1718236800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/T002093\/1"],"award-info":[{"award-number":["MR\/T002093\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the association between the sidedness of orofacial clefts and additional congenital malformations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Linkage of a national registry of cleft births to national administrative data of hospital admissions<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>National Health Service, England<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>2007 children born with cleft lip\u2009\u00b1\u2009alveolus (CL\u2009\u00b1\u2009A) and 2724 with cleft lip and palate (CLP) born between 2000 and 2012.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcome measure<\/jats:title>\n                    <jats:p>The proportion of children with ICD-10 codes for additional congenital malformations by the sidedness (left, right or bilateral) of orofacial clefts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      For CL\u2009\u00b1\u2009A phenotypes, there was no evidence for a difference in the prevalence of additional anomalies between left (22%, reference), right (22%, aOR 1.02, 95% CI 0.80 to 1.28;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.90) and bilateral clefts (23%, aOR 1.09, 95% CI 0.75 to 1.57;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.66). For CLP phenotypes, there was evidence of a lower prevalence of additional malformations in left (23%, reference) compared to right (32%, aOR 1.54, 95% CI 1.25 to 1.91;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001) and bilateral clefts (33%, aOR 1.64, 95% CI 1.35 to 1.99;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The prevalence of additional congenital malformations was similar across sidedness subtypes with CL\u2009\u00b1\u2009A phenotypes but was different for sidedness subtypes within CLP cases. These data support the hypothesis that CL\u2009\u00b1\u2009A has a different underlying aetiology from CLP and that within the CLP phenotype, right sided CLP may lie closer in aetiology to bilateral CLP than it does to left sided CLP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10556656241261918","type":"journal-article","created":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T14:35:27Z","timestamp":1718289327000},"page":"1504-1515","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Cleft lip Sidedness and the Association with Additional Congenital Malformations"],"prefix":"10.1177","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7776-2877","authenticated-orcid":false,"given":"Matthew","family":"Fell","sequence":"first","affiliation":[{"name":"Spires Cleft Centre, John Radcliffe Hospital, Oxford, UK"},{"name":"Bristol Dental School"},{"name":"University of Bristol"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2385-3172","authenticated-orcid":false,"given":"Kate J.","family":"Fitzsimons","sequence":"additional","affiliation":[{"name":"The Royal College of Surgeons of England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J.","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Queen Elizabeth University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jibby","family":"Medina","sequence":"additional","affiliation":[{"name":"The Royal College of Surgeons of England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5867-2625","authenticated-orcid":false,"given":"Sophie","family":"Butterworth","sequence":"additional","affiliation":[{"name":"The Royal College of Surgeons of England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Hae","family":"Park","sequence":"additional","affiliation":[{"name":"London School of Hygiene and Tropical Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Van der Meulen","sequence":"additional","affiliation":[{"name":"London School of Hygiene and Tropical Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Lewis","sequence":"additional","affiliation":[{"name":"Bristol Dental School"},{"name":"University of Bristol"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Chong","sequence":"additional","affiliation":[{"name":"The Royal Children's Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig JH","family":"Russell","sequence":"additional","affiliation":[{"name":"Royal Hospital for Children"},{"name":"Queen Elizabeth University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,6,13]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12663-010-0132-6"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000337464"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60695-4"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41415-023-6000-9"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9926(199911)60:5<265::AID-TERA7>3.0.CO;2-H"},{"key":"e_1_3_2_7_2","first-page":"105566562312210","article-title":"Sidedness in unilateral orofacial clefts: A systematic scoping review","author":"Fell M","year":"2023","unstructured":"Fell M, Bradley D, Chadha A, et al. 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